Anesthesia for Endocrine Disease Flashcards
Diabetes Mellitus
Insulin deficiency or decreased sensitivity to insulin
What are the clinical signs of Diabetes Mellitus?
PU/PD
Polyphagia with weight loss
Cataracts in Dogs
What are the clinical pathology findings of Diabetes Mellitus?
Hyperglycemia
glucosuria
Increased ALP
When should Diabetes Mellitus animals be anesthetized?
Only when correcting a life-threatening condtion
What is required before emergency anesthesia with Diabetes Mellitus?
Aggressive fluid therapy
Insulin therapy
Dextrose
Potassium supplementation
What is included in pre-op for Diabetes Mellitus?
CBC Chemistry with electrolytes Routine overnight fast give 1/2 normal AM insulin dose Check Blood Glucose before induction Treat hypoglycemia as needed Verify normoglycemia before administering drugs
What drugs should you avoid with Diabetes Mellitus?
Alpha 2 agonists
What can cause hyperglycemia?
Alpha 2 agonists
How do alpha 2 agonists cause hyperglycemia?
inhibition of insulin release or stimulation of glucagon release
How often do you check Blood Glucone with Diabetes Mellitus during anesthesia?
every 30-60 mins
What is the level of blood glucose maintained during anesthesia?
150-250mg/dL
What do you do to treat low Blood glucose during anesthesia?
1-5% dextrose in balanced electrolyte solution
What do you do post-op for a patient with Diabetes Mellitus?
Continue monitoring Blood Glucose every 1-2 hours until the patient is eating
Return to normal feeding schedule ASAP
Adjust insulin dose if anorexic
Insulinoma
Insulin-secreting tumor of pancreatic beta cells
What age dogs are insulinomas common?
9-10 year olds
What drugs do you administer to stabilize an insulinoma before surgery?
Glucocorticoids
Diazoxide
What should you do while the patient is under anesthesia for an insulinoma?
Monitor BG
Supplement Dextrose
Add glucocorticoids if necessary
Consider glucagon if unable to maintain with dextrose and glucocorticoids
What level should you keep BG at for an animal with an insulinoma under anesthesia?
greater than 50mg/dL
What are the two types of Diabetes Insipidus?
Central
Nephrogenic
What is Central DI?
ADH deficiency
What is Nephrogenic DI?
Renal insensitivity to ADH
What are the clinical signs of DI?
PU/PD
How do you treat Central DI?
Desmopressin
What should you NEVER do with Diabetes Insipidus fdor anesthesia?
Restrict water
What should you check in a patient with Diabetes Insipidus before induction?
Na levels
What level should Sodium be maintained at?
160mg/dL
What fluids should you use for Diabetes Insipidus under anesthesia?
hypotonic fluids
5% dextrose in water
.45% NaCl + 2.5% Dextrose
What is a common finding in animals with Hypothyroidism?
Bradycardia
Hypothermia
Hypoventilation
What is a common finding in cats with hyperthyroidism?
Thickened myocardium - thyrotoxic cardiomyopathy
murmur or a gallop
hypertension
tachyarrythmias
What do you do for pre-op in an animal with hyperthyroidism?
Minimize stress
What is possible to happen with hyperthyroidism under anesthesia?
“thyroid storm”
Thyroid Storm
Catecholamine release
increased HR, BP
arrhythmias
hyperthermia
What drugs should you avoid with hyperthyroidism under anesthesia?
Avoid drugs that increase HR, myocardial work, and oxygen consumption: Ketamine, Routine anticholinergics
Avoid drugs that result in significant CV changes: Acepromazine and Alpha 2 agonists
Avoid mask or chamber induction
What should you monitor for in a hyperthyroid patient under anesthesia?
HR
BP
Avoid tachycardia
What drug can be used with a patient with hyperthyroidism for Bp support?
Dopamine
Hyperparathyroidism
Excess production of PTH causing hypercalcemia
What is indicated in patients with hyperparathyroidism?
Surgery to remove the tumor
What should you do before anesthesia in a patient with hyperparathyroidism?
decrease serum iCa
What do you use to decrease serum iCa in a patient with hyperparathyroidism?
Fluid therapy with .9% NaCl
Diuretics
Steroids
What does marked chronic hypercalcemia cause?
ventricular arrhythmias
What drugs do you want to avoid in a patient with hyperparathyroidism?
Avoid long acting drugs or those that cause significant CV effects
What frequently occurs after surgery with an animal with hyperparathyroidism?
Hypocalcemia
How do you treat the hypocalcemia that results from surgery in a patient with hyperparathyroidism?
Ca gluconate
PO calcium
Hypoadrenocorticism
Decreased glucocorticoid and mineralocorticoid production by the adrenal glands
What is Atypical Addison’s?
decreased glucocorticoids only
What results from Hypoadrenocorticism?
Hypoglycemia Hyperkalemia Hyponatremia hypovolemia increased BUN
Addisonian Crisis
Hypoglycemia
hyperkalemia
Hyponatremia
hypovolemic shock
What should be done pre-op for Hypoadrenocorticism?
Recent bloodwork for electrolytes and blood glucose
continue administering scheduled PO gluco- or mineralocorticoids the morning of surgery
Consider administering a physiologic dose steroid IV at the time of induction
What drug should be avoid in patients with hypoadrenocorticism?
etomidate
What should you treat and monitor in a patient with hypoadrenocorticism?
Hypoglycemia
electrolyte abnormalities
What do you do Post-op for a patient with hypoadrenocorticism?
Restart chronic PO steroid ASAP
Monitor for signs of adrenal insufficiency
Recheck BG, electrolytes as needed
Hyperadrenocorticism
Excessive adrenal hormones
What are the two types of hyperadrenocorticism?
Pituitary dependent
Non pituitary dependent
What are the clinical issues associated with hyperadrenocorticism?
Hypertension
Hypercoagulability Hepatomegaly
Poor Immune function and wound healing
What are animals with hyperadrenocorticism susceptible to?
Pulmonary thromboembolism or thrombosis at other sites
Pre-op for Hyperadrenocorticism
Serum Chemistry and CBC
Baseline blood pressure
What should you monitor in an animal with hyperadrenocorticism?
arterial blood pressure
Monitor for PTE
What is a sign for Pulmonary Thromboembolism (PTE)?
Sharp drop in EtCO2
What do patients undergoing adrenal-suppressive therapy develop post-op?
adrenal insufficiency due to stress
How would you treat a patient with adrenal insufficiency due to stress associated with Hyperadrenocorticim?
Low-dose steroid treatment
Pheochromocytoma
tumor of the adrenal medulla producing epinephrine and norepinephrine
What is a clinical finding in patients with Pheochromocytoma?
Tachyarrythmias
Hypertension
Why is the surgery difficult for Pheochromocytoma?
high vascularity
potential for catecholamine release secondary to tumor handling
Pre-op for Pheochromocytoma
Stabilize BP and HR
What drug do you use to stabilize BP and HR in a patient with Pheochromocytoma?
phenoxybenzamine
What drugs do you use to control HR in a patient with Pheochromocytoma?
Beta Blockers
What drugs should you avoid in patients with Pheochromocytoma?
Drugs that cause tachycardia or vasoconstriction: Ketamine, Alpha 2 agonists, or Pre-anesthetic atropine
What do you monitor in a patient with Pheochromocytoma?
HR and BP
What do you use for tachyarrythymias in animals with Pheochromocytoma?
Beta Blockers
What can occur upon removal of Pheochromocytoma?
acute drop in catecholamines causing hypotension and cradycadia
How would you treat a drop in catecholamines?
Dobutamine
ephedrine
phenylephrine
Post-op for Pheochromocytoma
Hospitalize for at least 48 hours
Monitor ECG and BP
Monitor BG