NS Embryology Flashcards

1
Q

From what germ layer is the nervous system derived from?

A

Ectoderm

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2
Q

What is a chordoma?

A

A slow growing tumor from cellular remnants of notochord in adults

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3
Q

What parts of the NS are derived from the surface neuroectoderm?

A

Anterior pituitary
Lens and cornea

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4
Q

What parts of the NS are derived from the neural tube?

A

Brain
Spinal cord
Posterior pituitary
Retina and optic N
Skeletal motor neurons
Axons of preganglionic ANS
Oligodendrocytes

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5
Q

What parts of the NS are derived from neural crest cells?

A

CN ganglia
Spinal/dorsal root ganglia
SyNS chain and pre-aortic ganglia
Sensory N
PsNS ganglia of GI tract
Postganglionic ANS
Schwann cells
Glial cells
Pia and arachnoid mater

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6
Q

Around what day does the cranial neuropore close?

A

Day 25

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7
Q

Around what day does the caudal neuropore close?

A

Day 27 or 28

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8
Q

What are the 3 primary brain vesicles developed from neural tube?

A

Forebrain vesicle - prosencephalon
Midbrain vesicle - mesencephalon
Hindbrain vesicle - rhombencephalon

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9
Q

What are characteristics of spina bifida occulta?

A

Failure of caudal neuropore to close
Normal spinal cord
Skin over affected area contains tufts of hair
Vertebral arches fail to fuse around spinal cord
Maternal AFP does not increase

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10
Q

What are characteristics of meningocele/spina bifida cystica?

A

Failure of caudal neuropore to close
Arachnoid and pia maters protrude through the spines to form cystic swelling
Maternal AFP increases

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11
Q

What are characteristics of a meningomyelocele?

A

Cystic sac contains the spinal cord and nerves
Covered by a thin, friable vascular membrane
Failure of caudal neuropore to close

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12
Q

What are characteristics of anencephaly?

A

Failure of cranial neuropore to close
Increased maternal AFP
Polyhydramnios
Incompatible with life

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13
Q

What are the parts of the prosencephalon by week 5?

A

Telencephalon
Diencephlon

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14
Q

What are the parts of the rhombencephalon by week 5?

A

Metencephalon
Myelencephalon

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15
Q

What develops from the telencephalon?

A

Cerebral hemispheres
Interventricular foramen
Lateral ventricle

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16
Q

What develops from the diencephalon?

A

Thalamus
Hypothalamus
Posterior pituitary
Optic vesicle
Third ventricle

17
Q

What develops from the mesencephalon?

A

Midbrain
Cerebral aqueduct

18
Q

What develops from the metencephalon?

A

Cerebellum
Pons
Fourth ventricle

19
Q

What develops from the myelencephalon?

A

Medulla oblongata

20
Q

What are the three horns that develop into spinal cord?

A

Ventral motor horn
Dorsal sensory horn
Intermediate horn

21
Q

What is contained in the intermediate horn of the spinal cord?

A

Sympathetic neurons of ANS
Only present between T1 to L3

22
Q

What are the three groups of motor nuclei in the basal plate of the medulla?

A

Medial somatic efferent - hypoglossal nucleus
Intermediate special visceral efferent - neurons of CN XI, X, and IX
Lateral general visceral efferent - motor neurons to viscera

23
Q

What are the three groups of sensory nuclei in the alar plate of the medulla?

A

Lateral somatic afferent - general sensory - related to CN IX
Intermediate afferent - special - nucleus tractus solitarius
Medial visceral afferent - general from vagus

24
Q

What are the 3 groups of motor neurons in the pons?

A

Medial somatic efferent - abducens N
Special visceral efferent - trigeminal and facial Ns
General visceral efferent - supply submandibular and sublingual glands via facial N

25
Q

What are the 3 groups of sensory relay nuclei in the pons?

A

Lateral somatic afferent - trigeminal N
Special afferent
General visceral afferent

26
Q

What are the 2 groups of motor nuclei in the midbrain?

A

Medial somatic efferent - oculomotor and trochlear Ns
Small general visceral efferent group - Edinger Westphal nucleus - innervates sphincter pupillae

27
Q

What are the 2 colliculi of the alar plate of the midbrain?

A

Posterior colliculi - synaptic relay for auditory reflexes
Anterior colliculi - correlation and reflex centers for visual impulses

28
Q

What is the most common cause of hydrocephalus in a newborn?

A

Obstruction of aqueduct of Sylvius/cerebral aqueduct