non HIV & HIV pharm - Exam 1A

Question 1

what class is Acyclovir

Answer 1

Anti-viral (non-HIV)

Question 2

Acyclovir indications

Answer 2

HSV 1&2
Herpes zoster
Chickenpox/varicella

Question 3

Acyclovir SE

Answer 3

GI distress
Renal impairment
Seizures
ITP (idiopathic thrombocytopenia)
Tissue necrosis w/ IV route

Question 4

Acyclovir nursing considerations

Answer 4

Not a cure

Monitor pt with low platelet counts

Question 5

what class is Oseltamivir (tamiflu)

Answer 5

Anti-viral (non-HIV)

Question 6

Oseltamivir (tamiflu) MOA

Answer 6

Inhibit neuraminidases in influenza viruses

Question 7

Oseltamivir (tamiflu) indications

Answer 7

Prophylaxis and to treat active flu disease (48hr of sx onset)
Swine flu

Question 8

Oseltamivir (tamiflu) SE

Answer 8

N/v
Seizures
Renal impairment

Question 9

Oseltamivir (tamiflu) nursing considerations

Answer 9

Most active against flu A

Has to be started before or within 48 hrs of symptom onset

Only given to elderly & immunocompromised after known exposure

Question 10

what class is Ganciclovir

Answer 10

Anti-viral (non-HIV)

Question 11

Ganciclovir MOA

Answer 11

Inhibits viral DNA polymerases resulting in chain termination

Question 12

Ganciclovir indication

Answer 12

Cytomegalovirus (CMBV -> immuno comp pts)

Question 13

Ganciclovir SE

Answer 13

Very toxic
Nephrotoxic if given with other nephrotoxic drugs

Question 14

Ganciclovir nursing considerations

Answer 14

BBW: hematologic toxicity, fertility impairment, fetal toxicity, carcinogenesis

Don’t give with imipenem cilastatin bc seizure potential

Do not crush or split d/t skin irritation

Question 15

what class are NTRIs

Answer 15

antiretrovirals

Question 16

NTRIs MOA

Answer 16

Inhibits reverse transcriptase which blocks HIV to incorporate into the host cells DNA

Question 17

NTRIs indications

Answer 17

HIV

Question 18

NTRIs SE

Answer 18

Peripheral neuropathy
Pancreatitis
Lipoatriphy
Hepatic steatosis

Question 19

NTRIs nursing considerations

Answer 19

Usually give 2 of these

BBW: lactic acidosis syndrome

Question 20

Acyclovir MOA

Answer 20

1)interferes with viral nucleic acid synthesis, its regulation or both (DNA & RNA)
2)prevents virus from binding to cells so virus cannot get into cells preventing replication
3)stimulates the body’s immune system to kill the virus