Neurotransmitters 2 Flashcards

1
Q

What are catecholines?

A

number of neurotransmitters such as adrenaline, noradrenaline and dopamine.

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2
Q

Where is Ach distributed?

A

widely. e.g. Hippocampus, basal forebrain, neuromuscular junctions, autonomic nerves

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3
Q

WHat is Ach in association with?

A

memory/coordination/sleep/mood/aggression

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4
Q

How s Ach made?

A

AcetylcoA+choline —> Ach + CoA

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5
Q

What enzyme forms Ach?

A

Choline acetyltransferase

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6
Q

What enzyme breaks down Ach?

A

Acetylcholine esterase

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7
Q

What blocks Ach muscurinic receptors?

A

Atropine (ANTAGONIST)

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8
Q

What blocks Ach nicotinic receptors?

A

curane and a-bungarotoxin

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9
Q

where is dopamine produced?

A

substantia nigra and ventral tegmental area

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10
Q

WHat is the process of catecholamines synthesis?

A

Tyrosine, dopa, dopamine, norepinephrine, epinephrine.

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11
Q

What converts tyrosine to dopa?

A

tyrosine hydroxylase

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12
Q

What converts dopa to dopamine?

A

dopa decarboxylase

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13
Q

What is the pathology of parkinsons?

A

diminished substantia nigra (less dopamine)

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14
Q

Is there sensory loss in parkinsons?

A

No- motor component loss

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15
Q

Give some symptoms of parkinsons

A

shufflinf gait, tremor, rigidity.

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16
Q

in Parkinsons, where does inhibition in motor function come from?

A

the striatum

17
Q

What can be used to treat parkinsons?

A

L-dopa,
cocaine (blocks reuptake of dopamine)
amphetamine

18
Q

What may induce parkinsons?

A

Antiphyscotic drugsthat act on DA receptors

used to treat schizophrenia

19
Q

WHat is the principle site for noradrenaline?

A

locus coerulus (in PONs)

20
Q

Where is serotonin synthesised ?

A

Neurons clustered together in brain stem - RAPHE NUCLEI

21
Q

give some functions of serotonin

A

Arousal/consciousness
circadium rhythms
mood

22
Q

What can be used to treat depression?

A

serontonin reuptake inhibitors - tricyclics

MAO-A inhibitors prevents serotonin breakdown