Human CNS development and spinal cord Flashcards

1
Q

What happens to nerve conduction velocities during development?

A

They increase

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2
Q

What is caused when spinal cord fails to close at caudal end?

A

Spina bifida

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3
Q

WHat is caused when spinal cord fails to close at rostral end?

A

Anencephaly

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4
Q

What can prevent most neural tube defects?

A

folic acid - contain Vit B

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5
Q

What are the primary brain vesicles? (from most rostral end)

A

They are fluid filled swellings -

Prosencephalon, Mesencephalon, Rhomencephalon and spinal cord.

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6
Q

What are the secondary brain vesicles?

A

Prosencephalon divides into telencephalon, diencephalon and optic vesicles.
Rhombencephalon changes to metencephalon and mylencephalon.

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7
Q

What does white and grey mater contain?

A

White matter - processes

Grey matter- neuronal cell bodies

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8
Q

Where does the medulla oblongata develop from?

A

myelencephalon (hindbrain)

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9
Q

What is an interneuron?

A

Neurons that connect between sensory and motor neurons. a sensory neuron can activate multiple interneurons

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10
Q

What are the 3 spinal cord meninges?

A

Pia mater, arachnoid, dura mater.

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11
Q

What are the 2 spaces in meninges?

A
subarachnoid space (between pia mater and arachnoid mater)
Subdural space (between arachnoid and dura mater)
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12
Q

What happens at rostral end to dura mater?

A

It splits into 2. The inner meningeal layer and endosteal layer.

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13
Q

What separates inner meningeal layer and endosteal layer

A

dura sinus

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14
Q

Where is cerebral spinal fluid found?

A

In central canal, brain ventricles and subarachnoid space

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15
Q

What secretes CSF?

A

choroid plexuses (mainly in ventricels)

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16
Q

How can CSF be sampled?

A

Lumbar puncture between 3rd and 4th vertebrae (no spinal cord here)

17
Q

What can disturbances in fluid flow cause?

A

hydrocephalus

18
Q

What is the blood brain barrier?

A

physiological barrier that separates blood and CSF. Caused by astrocytes causing capillary endothelial cells to form tight junctions.

19
Q

What is the neaural tube?

A

A hollow tube from which the brain and spinal chord form from during development.

20
Q

What can absorb CSF?

A

arachnoid villi