neurotoxins

Question 1

what are the two predominant neurotoxins ?

Answer 1

Clostridium tetani
Tetanospasmin

Clostridium botulinum
Botulinum toxin

Question 2

Tetanospasmin BLOCKS which neurotransmitter ?

Answer 2

Blocks the release of the inhibitory neurotransmitters GABA and glycine

Question 3

when there is a block of the inhibitory neurotransmitters such GABA and glycine what are the clinical features ?

Answer 3

resulting in continuous motor neuron activity → continuous muscle contraction → lockjaw and respiratory paralysis

Question 4

Botulinum toxin blocks which neurotransmitter ?

Answer 4

Blocks acetylcholine (ACh) release

Question 5

blockage of ACH release leads to what clinical feature ?

Answer 5

flaccid paralysis