Myasthenia Gravis Flashcards
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which receptor is involved in the proximal muscle weakness of myasthenia gravid ?
Skeletal muscle contraction is dependent on acetylcholine which activates ! NICOTINIC ACETYLCHOLINE RECEPTORS!
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Clinical features
proximal myopathy
complex ophthalmoplegia
with evidence of fatigability of muscles on repetition
what are the complex ophthalmoplegia ?
drooping of eye - ptosis
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Diagnosis of myasthenia graves ?
Gell and Coombs hypersensitivity - TYPE 5
Nerve conduction studies show a decrement with repetitive nerve stimulation testing.
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Mx of myasthenia gravis
Pyridostigmine
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Anterior mediastinal mass + symptoms of myasthenia
Thyoma
= occasional breathing difficulty
= difficulty swallowing
need CT scan of the chest