Neurocognitive Disorders COMPLETE Flashcards

1
Q

What do we mean by late life

A

Life expectancy increasing dramatically:
Medical advancements and improved living conditions
Old usually defined as over 65- not universal- depends on the context.
In Ireland-determined by the pension age/ retirement age

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are the correlations between mental health and late life

A

Decline in cognitive and physical abilities
But they experience less negative emotions than young people

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Why do they experience less negative emotions?

A

They’re more skilled in emotional regulation
Focus on more emotional, meaningful goals
They process negative events less
The pressures they experience in life decrease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Talk about the incidence of psychological disorders in old people

A

Older people have less psychological disorders
Newer disorders are very unlikely in late life

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Why are the reasons which may influence the incidence of psychological disorders in old people

A

The stigma is reduced in young people, older people may be too embarrassed to speak up
Under- diagnoses
Misdiagnosis
Survivor bias- if they experienced issues younger in life, may have died

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What issues are looked into in regards to old people?

A

Age effects- the consequences of being a certain age- correlationary side
Cohort effects- the consequences of growing up during a particular time periodic. During war, after war
(Born after war had more bad mental health than during war)
Time of Measure effects- Things that happen during the time of research that interfere, ie. Doing a study on loneliness but then covid happens.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What are the research methods in the study of ageing?

A

Cross sectional studies
Longitudinal studies

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Describe cross sectional studies

A

Comparing a variable interest between different age groups at same time

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What study was conducted as a cross sectional study for ageing

A

Charles (Positivity Bias)
Memory test regarding images
Older people remembered less of the material in every condition
But they remember more of the positive items than the negative items

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What’s the issue with cross sectional studies

A

Cant rule out the cohort effect

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What are longitudinal studies

A

Periodically testing one group of people using the same measure over a number of years
Use a cohort of people who share defining characteristic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What did Snow et al study?

A

Nuns studied
When they examine the autobiography, those that used more positive feelings in their autobiography, they lived longer.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What’s the difference between cross-sectional and longitudinal studies

A

They produce very different results
Cross-sectional doesn’t take into account that cohorts may differ in access to education/work

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is dementia caused by?

A

Brain damage by diseases like Alzheimer’s
The symptoms depend on the parts of the brain that are damaged and by the disease that caused it.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Whats the most leading cause of dementia?

A

Alzheimer’s- 60-80%.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is the prevalence of dementia

A

1-2% of people in their 60s
20% of people above 85.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What are some warning signs of dementia

A

Problems with language
Memory loss
Disorientation
Problems with keeping track of things

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What is the trajectory of dementia?

A

150 million people world wide in 2050
Increases disproportionately in low and moderate income countries-may be due to lifestyle and health related risks
This is due to the increases in life expectancy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What are some risk factors associated with preventing dementia

A

12 modifiable risk factors can prevent/delay the onset of dementia
Examples Include:
Smoking
Depression
Obesity
Alcohol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Talk about potential and dementia prevention

A

Greater potential for dementia prevention in LMIC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

What other ways can dementia be prevented?

A

The finger study- ngandu
Cognitive training programs

22
Q

What was the finger study

A

Ngandu conducted double blind randomised trial on ppl ages 60-77
Intervention was 2 years of diet and exercise and cognitive training
Control received general health advice
Intervention group symptoms improved

23
Q

What are cognitive training programs

A

Controversial, may be that companies are profiting without it actually being beneficial
HAs been some slight improvement in people with cognitive impairment
Studies mostly inefficient to show the effects

24
Q

What is Alzheimer’s disease

A

Degenerative disease which causes irreversible deterioration of brain tissue- loss of grey matter
Short term memory loss is a common symptom
Accounts for 60-80% of dementia
Death usually occurs within 12 years of the onset of symptoms

25
What symptom is present at the early stage of Alzheimer's
Absent-mindedness
26
What symptoms are present as Alzheimer develops
Inability to find right words Lack of visual/spatial skills
27
What is the pathophysiology of Alzheimer
Plaques- beta-amyloid protein outside neurons Neurofibrillary tangles- protein tou inside axons of neurons
28
What gene predispose people for Alzheimer’s and which protects against it
APOE4- Apolioprotein E4 APOE2
29
Why does APOE4 effect Alzheimer’s
Not well understood The protein helps carry cholesterol in the blood stream Problems with brain cells ability to process fats/lipids may play a key role in Alzheimer's
30
What are the types of treatment for Alzheimer's
No disease-modifying treatment Medication can help slow decline but they don’t restore memory function to previous levels
31
What medication is used to treat alzehimers
Cholinesterase inhibitors
32
What are other forms of alzehimers treatment
Behavioural approaches, visual aids Music therapy
33
What are the psychological and lifestyle treatments for Alzheimers
Psychotherapy for patients and families Caregiver interventions- increasing social support, pleasant activities, exercise
34
How is Alzheimer early detected?
Beta amyloid plaques may be present 20-30 years before any cognitive symptoms- not reversible Genetic markers are detectable from birth
35
What’s frontotemporal Dementia
Caused by a loss of neurons in frontal and temporal regions of the brain Build up of proteins, liked to ALS Younger onset- mid to late 50’s
36
What’s FTD prevalence
Less than 1% of the population
37
What are the variants of FTD
Behavioural variant Primary progressive aphasia PPA variants
38
Explain Behavioural Variant of FTD
Decreased empathy Personality changes Increased compulsivity
39
Explain Primary progressive aphasia PPA variants
Semantic dementia- naming things, ppl losing meaning of words Progressive non-fluency aphasia- pronouncing things Logopenic aphasia- speaking slowly
40
What is the medication treatment for FTD
Medication Antidepressants- to treat depression and compulsivity Antipsychotics- severe agitation and compulsivity
41
What are some non-pharmacological treatements for FTD
Family therapy Speech therapy
42
Lewy body dementia
Caused by abnormal deposits of protein alpha - synuclein Lewy bodies affect chemicals in the brain- leads to thinking and behavioural problems Onset age 50 years- die after 5-8 Often misdiagnosed due to similar symptoms w other conditions
43
What are the symptoms of Lewy Bodies
Visual hallucinations/ disorganised thinking/memory problems Depression/ severe agitation/paranoia Tremor/balance issues /slow movement Insomnia/ REM behaviour disorder
44
What is the medication treatment for the cognitive symptoms of Lewy body dementia
Cholinesterase inhibitor
45
What is the medication treatment for the movement symptoms of Lewy body dementia
Levodopa
46
What is the medication treatment for the REM sleep behaviour for Lewy body dementia
Clonazepam/melatonin
47
What is the medication treatment for the depression for Lewy body dementia
Anti depressants
48
What is the medication treatment for the severe agitation/paranoia?
Anti psychotics
49
What are the non- pharmacological treatments for levy body dementia
Physical therapists Occupational therapists Speech therapists
50
What is delirium?
A clouded state of consciousness Trouble focusing Disturbances in sleep/wake cycle Within 24 hours, they have lucid intervals where they become alert and coherent
51
What are the contributing factors of delirium
Medication Infection surgery alcohol Drug intoxication/withdrawal