Mood Disorders (COMPLETE) Flashcards
What is mood?
A prolonged emotional state
What are mood disorders?
Gross deviations in mood
What are mood disorders composed of?
Different types of mood episodes that last days or weeks.
What are the types of mood episodes?
Major depressive episodes-lose limit of normal mood
Manic episodes- top limit of normal mood
Hypomanic episodes- upper limit of normal mood
What is the DSM 5 criteria for Major Depressive Mood Disorder?
A5 or more of the following symptoms which:
Must be present almost everyday during the same 2 week period.
Represent a change from previous functioning
NB: At least one symptom must be depressed mood or loss of interest/pleasure
1.Depressed mood
2. Diminished interest/pleasure
3. Weight gain/loss of appetite
4. sleep disturbance
5. Psychomotor agitation/ psychomotor retardation
6. Fatigue/loss of energy
7. Feelings of worthlessness/guilt
8. diminished ability to think/concentrate
9. recurrent thoughts of death/suicide idealation
B. Must cause significant distress/impairment
C. Cannot be attributable to any other medical condition
Why is clinical judgement important when diagnosing major depressive disorder?
You shouldn’t diagnose MDD if it could be better explained by another disorder, ie. schizophrenia.
Responses to a loss may resemble a depressive episode under the 1st criteria
What did persistent depressive disorder used to be called?
dysthymia
What is the DSM 5 criteria for persistent depressive disorder?
Depressed mood for most of day/more days than not for at least 2 years/ 1 for children and adolescents
At least 2 of the following:
1. Poor appetite/overreating
2. insomnia/ hypersomnia
3. Low energy/fatigue
4. Low self esteem
5. Poor concentration
6. Feeling hopeless
What’s the defining feature of persistent depressive disorder?
Chronicity
What are the new depressive disorders?
Disruptive mood dysregulation disorder
Premenstrual dysphoric disorder
Prolonged grief disorder
What is Disruptive mood dysregulation disorder
Recurrent temper outbursts and persistent negative mood for at least 1 year BEGINNING BEFORE AGE 10
What is premenstrual dysphoric disorder?
Mood symptoms the week before menses
Can get hormonal treatments or SSRIS
What’s the prevalence of depressive disorders?
6-21% lifetime prevalence.
2:1 female to male ratio
Age of onset from late teens to 20s
3 times higher in low socio-economic status
2nd leading contributor to the global burden of disease.
What are the possible reasons for gender differences in depressive disorders?
Stress in adolescence- body image, puberty etc
Girls are more likely to be victims of sexual abuse
Rate of reporting may be higher
What are common misconceptions about bipolar disorder?
MISCONCEPTION: That they shift back and forth from depression to mania very often
TRUTH: They experience one to two cycles a year.
MISCONCEPTION: Bipolar is just another term for mood swings
TRUTH: the changes in mood are more severe, last longer and interfere with important aspects of functioning.
Manic episodes usually involve reckless behaviour.
What is the criteria for manic and hypomanic episodes?
Distinct periods of abnormally and persistently elevated, expansive or irritable mood.
Abnormally increased activity/energy
At least 3 of the following being noticeably changed from the baseline (4 if mood is irritable):
- increased self esteem- belief that one has special talents
- Decreased need for sleep
- Unusual talkativeness
- Flight of ideas/thoughts racing
- Distractability
- Increase in goal directed activity
- excessive involvement in activities that have high pain consequence
What’s the difference between manic v hypomanic?
Hypomania is a lesser mania
Manic:
Longer in duration
Can experience/ not experience psychosis
Significantly impaired functioning
Hypomanic
Less duration
no psychosis
implied functioning not significant
What are the 3 kinds of bipolar disorder?
Bipolar 1 disorder: At least 1 manic episode during the courts of their life
Bipolar 2 disorder: At least one major depressive episode
At least one episode of hypomania
No lifetime episode of mania
Cyclothymic disorder
For at least 2 years or 1 for children and adolescents
numerous periods of hypomanic symptoms but no hypomanic episode
numerous periods of depressive symptom but no major depressive episode
What’s the prevalence of bipolar disorder?
Less than 1 percent
Bipolar 1 disorder is more common
Less than 50% of bipolar spectrum disorders begin before 25 years
No evidence for sex differences
Very high rates of comorbidity with other disorders, ie. substance most common for bipolar than any other
What are some specifiers for the subtypes of depressive and bipolar disorders?
Seasonal pattern
Psychotic features
Suicide risk
Atypical features
What is the genetic aetiology for Major depression and bipolar disorders?
Heritability of major depression is 37%
Bipolar disorders are amongst the most heritable of all psychiatric disorders - 80- 93
What is the controversy over single gene studies
Heritability data suggests there is a substantial genetic
contribution to depression
Lots of studies have implicated the serotonin transporter
gene.
However, complex traits like depression are hugely polygenic
Does stress have an effect on depression risk?
Does the s allele have an effect on depression risk?
Does the stress x gene have an effect on depression risk?
Yes
no
No
What do most people believe depression is caused by
A chemical imbalance
What neurotransmitters are said t be involved in the aetiology of mood disorders
Monoamine neurotransmitters:
Dopamine
Noradrenaline
Serotonin
What’s the evidence that serotonin is involved in mood disorders?
Is it true?
Drugs that treat depression fix the activity of serotonin
Low serotonin cerebrospinal fluid in depressed patients
Not true- no consistent evidence to show associations between serotonin and depression