Neurocognitive Disorder

Question 1

When does FTD typically occur?

Answer 1

Before age 60. It is a gradual process, not abrupt

Question 2

Neurocognitive disorders and OSA

Answer 2

OSA can worsen the severity of NCDs. There is a clear link.

Question 3

Most common EARLY alzheimers symptom

Answer 3

Apathy

Question 4

Which is acetylcholinesterase inhibitor is approved for the treatment of anticholinergic delirium?

Answer 4

Physostigmine

Question 5

Which test would show Most severe impairment in early NCD?

Answer 5

Weschler Memory Test

Question 6

Which alz drug is contraindicated in severe renal and severe hepatic dz?

Answer 6

Galantamine

Question 7

Trazodone and ALzq

Answer 7

Can be helpful if depression and insomnia are present.

Question 8

Alzheimer’s patients with asthma should beware of which medications?

Answer 8

History of asthma or COPD potentially can experience increased airway reactivity following cholinergic stimulation by such cholinesterase inhibitors as donepezil, galantamine, Rivastygmine

Question 9

Which cholinesterase inhibitor is the best in Alzheimer’s?

Answer 9

All are equal efficacy

Question 10

Delirium is associated with a change in which neurotransmitter?

Answer 10

Decrease in acetylcholine

Question 11

Normal aging of 75 yo

Answer 11

• decreased non-REM sleep
• under-reactive DTRs
• Decrease in brain weight to 85% of normal.
• Slowing of background alpha activity on EEG

Question 12

AIDS dementia complex

Answer 12

AIDS dementia complex (sometimes also called HIV-associated dementia), which causes symptoms such as encephalitis (inflammation of the brain), behavioral changes, and a gradual decline in cognitive function.

Question 13

Fluctuating cognition is which type of dementia?

Answer 13

Dementia with lewy body

Question 14

Pt taking rivastigmine oral gets nausea, vomiting, and diarrhea. What do you do?

Answer 14

The gastrointestinal disturbance with acetylcholinesterase inhibitors comprises of nausea, vomiting, and diarrhea. The current recommendation of management is the conversion of oral rivastigmine to administration via a transdermal patch

Question 15

What is the worse beta to deal with in Alzheimers?

Answer 15

Aβ1-42 is believed more prone to aggregation and possibly more pathogenic

Question 16

MAPT gene mutation is what?

Answer 16

Frontotemporal dementia

Question 17

Safe treatment for post operative delirium?

Answer 17

ondansetron

Question 18

The 5% rule with 65

Answer 18

Starting at age 65, there is a 5%-8% rate of alzheimers. It goes up 5% every 5 years.

Question 19

Visual hallucinations and donepezil

Answer 19

Actually has a chance to reduce visual hallucinations seen in LBD.

Question 20

Best neuroimaging to differentiate alzheimers from FTD?

Answer 20

PET to check out glucose metabolism

Question 21

Hepatic encephalopathy can cause which type of delirium?

Answer 21

Hypoactive

Question 22

What scan can be given to differentiate parkinsons tremor for essential?

Answer 22

SPECT should be considered for people with tremor where essential tremor cannot be clinically differentiated from Parkinsonism.

Question 23

First symptom to get hit by vascular NCD?

Answer 23

executive function

Question 24

Late onset Alzheimers is associated with what?

Answer 24

Hypertension/cerebrovascular disease

Question 25

What part of the brain is most often impacted in Alzheimer’s ?

Answer 25

Entorhinal cortex