Buzz Words Flashcards
Alpha Synuclein
Lewy Body Disease. It is one of 3 components (others are neurofilament and ubiquitin)
Tau protein
Alzheimer’s Disease (along with amyloid). Also seen in Pick’s dz.
Hyperphosphorylated Tau
Chronic Traumatic Encephalopathy (CTE)
Chromosome 17
FTDP-17 , Frontotemporal dementia and Parkinsonism linked to chromosome 17
Serial 7’s
Tests sustained attention
MMSE Shortcoming
Poor in recognizing executive dysfunction. May not pick up on FTD.
PET for Alzheimer’s
Helps differentiate Alz vs FTD . Medicare reimbursable.
Fast polyphasic waves on EEG
Creutzfeldt-Jacob, in the context of sx of slowing.
ApoE 4
Apolipoprotien E epsilon 4 allele is the main genetic risk despite being a vulnerability and not causal allele in Alzheimer’s Dementia
Amyloid Beta -42
The bad plaque in Alzheimer’s.
High n-3 Fatty acids, ApoE epsilon 2 allele, physical acitvity
protective factors for alzheimer’s
Presenilin 1 gene
Autosomal dominant transmission of alzheimers
Fluctuating cognition (NCD)
Lewy Body
REM behavior disorder in NCD
Lewy Body or in major NCD due to parkinsons. Acting out the dreams is a bad prognostic indicator.
Pick Bodies
large aggregates of protein, predominantly tau.
