Naloxone & Ondansetron Flashcards
Naloxone
Brand Name
Narcan
Naloxone
Class
Narcotic antagonist
Naloxone
Supply
prefilled syringe
Naloxone
Mechanism of Action
-acts as competitive antagonist at opiate receptors in the CNS
-reverses effects of narcotic and synthetic analgesic drugs: CNS depression, respiratory depression, respiratory arrest
Naloxone
Indications
-narcotic and synthetic analgesic drug overdose
(morphine, heroin, oxycodone, methadone, codeine, meperidine, fentanyl, hydrocodone, hydromorphone)
-unconsciousness of unknown etiology
Naloxone
Contraindication
-none in emergency setting
Naloxone
Adverse reactions
-withdrawal symptoms
such as:
-confusion
-hypotension
-tachycardia
-hypertension
-dysrhythmias
-diaphoresis
-nausea, vomiting
Naloxone
Routes
-IV
-IM
-IO
-ET
-IN
Naloxone
Onset
2-10 minutes
Naloxone
Adult Doses
- 2.0mg, may repeat every 2 minutes
-ET: 4.0mg diluted in 10mL NS
-IN: 1.0mg sprayed in each nostril with MAD. may repeat every 2 minutes
Naloxone
Pediatric Doses
- 0.1 mg/kg (max 2.0 mg per dose) may repeat every 2 minutes
-ET: 2.0-4.0 mg diluted in 3-5mL NS
-IN: 1.0mg sprayed in each nostril with MAD. may repeat every 2 minutes
Naloxone
Special Consideration
-duration is 20 minutes to 2 hours
Ondansetron
Brand Name
Zofran
Ondansetron
Class
Antiemetic
Ondansetron
Standard Supply
- orally disintegrating tablet (ODT)
-vial
Ondansetron
Mechanism of Action
-blocks serotonin 5-HT3 receptor sites in CNS
-inhibits nausea and vomiting
Ondansetron
Indication
nausea and vomiting
Ondansetron
Contraindication
known hypersensitivity
Ondansetron
Adverse reactions
-headache
-dizziness
Ondansetron
Routes
-oral
-IV
-IO
Ondansetron
Onset
5-10 minutes
Ondansetron
Adult Dose
- Oral: 8.0 mg
- IV/IO: 4.0-8.0 mg over 2-5 minutes
Ondansetron
Pediatric Dose
4-14 years old: 4.0 mg
max dose 4.0 mg
Ondansetron
Special Consideration
-peak effect is 2 hours
-duration of drug is 3-6 hours
