Magnesium Sulfate & Methylprednisolone

Question 1

Magnesium Sulfate

Classes

Answer 1

-electrolyte
- anti-inflammatory
-tocolytic (labor suppressant)

Question 2

Magnesium Sulfate

Supply

Answer 2

vial

Question 3

Magnesium Sulfate

Mechanism of Action

Answer 3

-decreases ventricular irritability
-decreases release of acetylcholine that inhibits muscular excitability
-causes uterine relaxation
-relaxes bronchial smooth muscle resulting in bronchodilation

Question 4

Magnesium Sulfate

Indications

Answer 4

-seizures caused by toxicity of pregnancy (toxemia)
-pregnancy induced hypertension (pre-eclampsia and eclampsia)
- pre-term labor
-tosades de pointes (polymorphic ventricular tachycardia)
-ventricular fibrillation and pulseless ventricular tachycardia refractory to amiodarone or lidocaine
-reactive airway conditions including bronchoconstriction and bronchospasm

Question 5

Magnesium Sulfate

Contraindication

Answer 5

-hemodynamically significant heart block

Question 6

Magnesium Sulfate

Adverse Reaction

Answer 6

-CNS depression
-drowsiness
-hypotension
-respiratory depression
-dysrhythmias

Question 7

Magnesium Sulfate

Routes

Answer 7

-IV
-IO
-infusion

Question 8

Magnesium Sulfate

Onset

Answer 8

immediate

Question 9

Magnesium Sulfate

Adult Dose
Torsade de Pointes infusion

Answer 9

Infusion: 1.0-2.0 G in 50-100 mL over 5 minutes. May repeat the dosage 1.0-2.0 G over 1 hour

Question 10

Magnesium Sulfate

Adult dose
Pre-term labor/Pre-eclampsia/Eclampsia

Answer 10

Infusion: 3.0-6.0 G in 100 mL over 10-20 mins. May repeat initial dosage.

Question 11

Magnesium Sulfate

Adult Dose
Maintenance infusion

Answer 11

1.0-4.0 G/hour

Question 12

Magnesium Sulfate

Adult Dose
Reactive Airway conditions

Answer 12

2.0 G in 50 mL over 5-10 mins

Question 13

Magnesium Sulfate

Adult Dose
Cardiac Arrest IV/IO

Answer 13

1.0-2.0 G over 1-2 mins

Question 14

Magnesium Sulfate

Pediatric Dose
Reactive Airway Conditions infusion

Answer 14

25-50 mg/kg of a 10% solution infused over 15-30 minutes. Max dose 2.0 G

Question 15

Magnesium Sulfate

Special Consideration

Answer 15

An infusion pump should be used to administer the drug when possible

Question 16

Methylprednisolone

Brand Name

Answer 16

Solu-Medrol

Question 17

Methylprednisolone

Classes

Answer 17

-corticosteroid
-glucocorticoid
-anti-inflammatory

Question 18

Methylprednisolone

Supply

Answer 18

Vial

Question 19

Methylprednisolone

Mechanism of Action

Answer 19

-suppresses acute and chronic inflammation
-produces immunosuppresive effect
-stabilizes cellular membranes

Question 20

Methylprednisolone

Indications

Answer 20

-acute exacerbation of asthma, chronic bronchitis, emphysema, and other reactive airway conditions
-anaphylaxis
-burns involving the airway

Question 21

Methylprednisolone

Contraindication

Answer 21

-none in the emergency setting

Question 22

Methylprednisolone

Adverse Reactions

Answer 22

-none for a single dosage

Question 23

Methylprednisolone

Routes

Answer 23

-IV
-IO

Question 24

Methylprednisolone

Onset

Answer 24

1-6 hours

Question 25

Methylprednisolone

Adult Dosage

Answer 25

-125 mg

Question 26

Methylprednisolone

Pediatric Dose

Answer 26

2.0-4.0 mg/kg

Question 27

Methylprednisolone

Special Considerations

Answer 27

-peak effect of the drug is 8 hours
-duration of the drug is 18-36 hours