Magnesium Sulfate & Methylprednisolone Flashcards
Magnesium Sulfate
Classes
-electrolyte
- anti-inflammatory
-tocolytic (labor suppressant)
Magnesium Sulfate
Supply
vial
Magnesium Sulfate
Mechanism of Action
-decreases ventricular irritability
-decreases release of acetylcholine that inhibits muscular excitability
-causes uterine relaxation
-relaxes bronchial smooth muscle resulting in bronchodilation
Magnesium Sulfate
Indications
-seizures caused by toxicity of pregnancy (toxemia)
-pregnancy induced hypertension (pre-eclampsia and eclampsia)
- pre-term labor
-tosades de pointes (polymorphic ventricular tachycardia)
-ventricular fibrillation and pulseless ventricular tachycardia refractory to amiodarone or lidocaine
-reactive airway conditions including bronchoconstriction and bronchospasm
Magnesium Sulfate
Contraindication
-hemodynamically significant heart block
Magnesium Sulfate
Adverse Reaction
-CNS depression
-drowsiness
-hypotension
-respiratory depression
-dysrhythmias
Magnesium Sulfate
Routes
-IV
-IO
-infusion
Magnesium Sulfate
Onset
immediate
Magnesium Sulfate
Adult Dose
Torsade de Pointes infusion
Infusion: 1.0-2.0 G in 50-100 mL over 5 minutes. May repeat the dosage 1.0-2.0 G over 1 hour
Magnesium Sulfate
Adult dose
Pre-term labor/Pre-eclampsia/Eclampsia
Infusion: 3.0-6.0 G in 100 mL over 10-20 mins. May repeat initial dosage.
Magnesium Sulfate
Adult Dose
Maintenance infusion
1.0-4.0 G/hour
Magnesium Sulfate
Adult Dose
Reactive Airway conditions
2.0 G in 50 mL over 5-10 mins
Magnesium Sulfate
Adult Dose
Cardiac Arrest IV/IO
1.0-2.0 G over 1-2 mins
Magnesium Sulfate
Pediatric Dose
Reactive Airway Conditions infusion
25-50 mg/kg of a 10% solution infused over 15-30 minutes. Max dose 2.0 G
Magnesium Sulfate
Special Consideration
An infusion pump should be used to administer the drug when possible
Methylprednisolone
Brand Name
Solu-Medrol
Methylprednisolone
Classes
-corticosteroid
-glucocorticoid
-anti-inflammatory
Methylprednisolone
Supply
Vial
Methylprednisolone
Mechanism of Action
-suppresses acute and chronic inflammation
-produces immunosuppresive effect
-stabilizes cellular membranes
Methylprednisolone
Indications
-acute exacerbation of asthma, chronic bronchitis, emphysema, and other reactive airway conditions
-anaphylaxis
-burns involving the airway
Methylprednisolone
Contraindication
-none in the emergency setting
Methylprednisolone
Adverse Reactions
-none for a single dosage
Methylprednisolone
Routes
-IV
-IO
Methylprednisolone
Onset
1-6 hours
Methylprednisolone
Adult Dosage
-125 mg
Methylprednisolone
Pediatric Dose
2.0-4.0 mg/kg
Methylprednisolone
Special Considerations
-peak effect of the drug is 8 hours
-duration of the drug is 18-36 hours
