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Drug Profiles > Lorazepam & Diazepam > Flashcards

Lorazepam & Diazepam Flashcards

1
Q

Lorazepam

Brand Name

A

Ativan

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2
Q

Lorazepam

Class

A

-benzodiazepine
-anticonvulsant
-sedative
-hypnotic

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3
Q

Lorazepam

Supply

A

vial

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4
Q

Lorazepam

Mechanism of Action

A

-produces sedation by acting on the limbic system, thalamus and cortex
-bind to GABA benzodiazepine receptors in the brain
-raises seizure threshold
-exerts tranquilizing action (antianxiety) of CNS

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5
Q

Lorazepam

Indications

A

-seizure activity
-status epilepticus
-procedural sedation of intubation and cardioversion
-chemical restraint for excited delirium

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6
Q

Lorazepam

Contraindication

A

known hypersensitivity

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7
Q

Lorazepam

Adverse Reactions

A

-sedation
-transient amnesia
-respiratory depression
-respiratory arrest
-bradycardia
-hypotension
-dizziness
-drowsiness
-blurred vision
-nausea, vomiting

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8
Q

Lorazepam

Routes

A

-IV
-IO
-IM

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9
Q

Lorazepam

Onset

A

IV/IO: 2-5 minutes
IM: 15-30 minutes

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10
Q

Lorazepam

Adult Dose
Seizures

A

IV/IO: 2.0-5.0 mg over 2 minutes
IM: 2.0-5.0 mg

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11
Q

Lorazepam

Adult Dose
Procedural Sedation

A

IV/IO: 2.0 mg over 2 minutes
IM: 4.0 mg
max dose 10 mg

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12
Q

Lorazepam

Pediatric Dose

A

Seizures IV/IO/IM: 0.05 to 0.1 mg/kg over 2 minutes
max dose 4.0 mg

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13
Q

Lorazepam

Special Consideration

A

drug may produce longer periods of sedation with elderly patients

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14
Q

Diazepam

Brand Name

A

Valium

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15
Q

Diazepam

Class

A

-benzodiazepine
-anticonvulsant
-sedative
-hypnotic

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16
Q

Diazepam

Supply

A

-vial
-ampule

17
Q

Diazepam

Mechanism of Action

A

-produces sedation by acting on limbic system, thalamus and hypothalamus
-binds to GABA benzodiazepine receptors in brain
-raises seizure threshold
-produces tranquilizing (antianxiety) effect on CNS

18
Q

Diazepam

Indications

A

-seizure activity
-status epilepticus
-procedural sedation for intubation and cardioversion
-chemical restraint for excited delirium
-delirium tremens

19
Q

Diazepam

Contraindication

A

-known hypersensitivity
-head injury

20
Q

Diazepam

Adverse Reactions

A

-sedation
-transient amnesia
-respiratory depression
-respiratory arrest
-bradycardia
-hypotension
-dizziness
-drowsiness
-blurred vision
-nausea, vomiting

21
Q

Diazepam

Routes

A

-IV
-IO
-IM
-rectal

22
Q

Diazepam

Onset

A

IV/IO: 2-5 minutes
IM: 15-30 minutes
rectal: variable

23
Q

Diazepam

Adult Dose

A

2.0 mg increments over 2 minutes

24
Q

Diazepam

Pediatric Dose

A

IV/IO: 0.2-0.3 mg/kg
IM: 0.1 to 2.0 mg/kg
rectal: 0.2-0.5 mg/kg

25
Q

Diazepam

Special Consideration

A

drug may be administered rectally to pediatric patients, but efficacy of rectal for adults has not been established

Drug Profiles (16 decks)

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