N3+4) Neurodegeneration and cognitive disorders Flashcards
neurodegenerative disorders alz parkisons, DLB MND FTLD CJD
what are the PROTEINS involved for each one pto for hints
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what diseases are these proteins associated with
aSyn TDP-43 tau FUS prion
what is seen on tissue pathology for neurodegenerative conditions
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neurodegenerative cond
prtein pathology
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for parkinsins and ALS what brain region, cell type and pathology is seen
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neurodegenerative clinical features in terms of cognitice domains
on back
memory executive language social-behaioural psychiatric visuo-spacial
what types of symptoms does: alz have FTD PCA PPA
what affects memory+
what affects visuospacial
social and executuive
language
what are the clinical syndomes that can present neurodegenerative patients, generally
what about for parkinsons, DB
what about for MND, FTD-MND
cxognition, psychiatric, behav, motor positive and negative, sleep, sensory, autonommic
clnical syndromes for:
what about for parkinsons, DB
what about for MND, FTD-MND
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imaging and disease progression, what is important to think about here.
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genes for the proteins! what is the most common one
what is the pathology of alzheimers disease
on slab
how and why does this occur
what is a consequence of this
cerebrain amyloid angiopathy
alzheimers disease
what changes occur in the brain, discuss these. pto for promt.
amyloid and tau
consequence of amylpid dep??
alzheimers and MRI
what can be seen and why, what does this show
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