Cancer) Biology Of Cancer

Question 1

Germ line vs somatic mutation

What ares one causative factors fo cancer

Answer 1

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Question 2

Hereditary cancer

What is it usually assoc with
Give eg of condition which is

Answer 2

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Question 3

Retinoblastoma

Diff between familial and sporadic?
What is it caused by

Answer 3

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Question 4

Rb gene

What happens normally what happen when it goes wrong

Answer 4

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Question 5

BRCA1 and BRCA2

What are they what do they do what are they involved with

Answer 5

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Question 6

What parameters are involved with risk of cancer develop,met

What are low mod high risk percentage
What would you do for each group
What things can be done to reduce the risk

Answer 6

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Question 7

How can BRCA1/2 gene be exploited in cancer treatment

What is this called

Answer 7

Displaying
PARP

Synthetic lethality

Question 8

CML
What is this, what is basic clinical features
What is the genetic basis for this

Answer 8

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Question 9

For CML, how does imatinib work

Answer 9

Comp binds substrate of BCR-ABL enzyme — tumour cant proliferate