I&I) Hepatitis Pathogenesis

Question 1

What are different stages of viral hepatitis

How can you stage hepatic fibrosis histologically

Answer 1

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Question 2

Talk though what happens when HBV enters the body — what is the general response

Answer 2

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Question 3

How and why can persistent HBV infection occur? Overview, list

Answer 3

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Question 4

HBV persistence. Why do these reasons cause it:
— immunosuppression
— HBV X protein
— Foxp3
— programmed death-1 receptor
— CTLA4
— IL10

Answer 4

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Question 5

How does IL10 cause persistent HBV infection? Also
— immunosuppression
— HBV X protein
— Foxp3
— programmed death-1 receptor
— CTLA4
— IL10

Answer 5

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Question 6

Talk through the serology of HBV. What things show what and when are they raised or high - chronic and acute.

Answer 6

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Question 7

HbsAg, HbsAb
HBeAg, HbeAb
HbcAg, HBcAb
Viral load

What do these mean and represent

Answer 7

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Question 8

Talk through the natural history of HBV and who is more likely to be resolved or chronic

Answer 8

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Question 9

What treatments are available for chronic HBV

Answer 9

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Question 10

Hepatitis C

What are some general facts about it, PTO hint

What is a somewhat rare complication of this and why and when does this happen

Answer 10

What type of virus, who develops chronic, vaccine

Question 11

Describe what happens in regards to HBC: viraemia, T cell responses and neutralising abs

In acute and chronic

Answer 11

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Question 12

What reasons are there for HBV chronicity

Answer 12

High replication rate
High error rate of RNA dependant RNA polymerase
HBV proteins
Neutralising AB

Question 13

Why HBV chronicity?

High replication rate
High error rate of RNA dependant RNA polymerase
HBV proteins
Neutralising AB

Answer 13

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Question 14

What is something that can genetically give you an advantage in repsponding to HCV

Answer 14

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Question 15

IL28B polymorphism — what is this lead to, how does this relate to HCV

Answer 15

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Question 16

Talk through the serology of HCV. Pto for hints.

What do they mean, how do levels differ with time and acute / chr

Answer 16

HCV-RNA, ALT, anti-HCV

Question 17

Give some examples of HCV drugs and classes where you can. PTO for the drug classes, try and name some and what do they do / involved with

Answer 17

NS3/4A protease inhibitors

NS5A inhibitors

NS5B polymerase inhibitors

Question 18

What type of drug is

Sofosbuvir
Dasabuvir

Answer 18

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Question 19

Ledipasvir
Ombitasvir
Daclatasvir
Elbasvir
Velpatasvir
Pibrentasvir

What type of drugs are these

Answer 19

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Question 20

Granzoprevir
Paritaprevir
Simeprevir
Glecaprevir

What types of drugs are these

Answer 20

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Question 21

Fibrosising Cholestatic hepatitis

What is, what are the features, who is it common in

Answer 21

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