Multiple Sclerosis

Question 1

What is MS
How does it go about creating the damage it does
Why may clinical presentations be diverse

Answer 1

Inflammation — blood brain barrier breaks down, mytelin is destroyed. Also axons, glial cells.
Sclerotic plaques

Question 2

Genetic factors with MS — what are the genes involved

What about viral factors

Answer 2

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Question 3

How is a diagnosis made

What could a differential be

Answer 3

What is DIS and DIT

Question 4

What are some positive sensory features of MS

Answer 4

Electric shock when bending neck

Symptoms worse after exertion or heat

Question 5

What is the effect of early relapses on long term disability?

What is a significant predictor of this?

What other factors affect long term disability

Answer 5

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Question 6

What lesion location is associated with best long term disability score?

How does lesion volume change with time? Also how does this vary between different MS types

Answer 6

Infratentorial lesions

Question 7

What parts of the brain is involved in MS pathology

what matter atrophy rate correlates with disability and lesion load over time

Answer 7

Both — now grey matter being increstigated

After its just GM atrophy rate after 20 years

Question 8

For someone with clinically isolated syndrome, what increases the risk of it progressing to S

Answer 8

Asymp spinal cord lesions

Gd+ lesions

Question 9

Long term MS effects

What is the risk of more severe disability down to

Answer 9

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Question 10

What are some treatments available for MS

What might you need to consider when prescribing

Answer 10

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Alemtuzumab
Terfunomide
Daclizumab
Dimethyl fumarate 
Glatiramer acetate