Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharmacology > MSK > Flashcards

MSK Flashcards

1
Q

NSAIDs examples

A 
Aspirin
Ibuprofen
Naproxen
Diclofenac
Celecoxb
Paracoxib
Etoricoxib
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

NSAIDs mechanism of action

A

inhibits COX by competing with arachidonic acid and reduce prostaglandin, prostacyclin and thromboxane synthesis
Anti-inflammatory, antipyretic and anti platelet

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

NSAID uses

A 
pain
inflammatory conditions
osteoarthritis
postoperative pain
platelet aggregation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

NSAID side effects

A

more with COX 1 inhibitor than COX 2
GI- dypepsia, nausea, Peptic ulcer
Renal- GFR
Cardiovascular- vasoconstriction, decrease antagonism of ADH and increase MI

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Paracetamol mechanism of action

A

COX-2 selective inhibition in CNS, reduce pain signals

Peroxidases in peripheral inflammation, limit action so little anti-inflammatory action

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Paracetamol uses

A

Mild-moderate analgesia and pain

non NSAID, Non ospitate analgesic with antipyretic action

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Paracetamol side effects

A

NAPQI- oxidation product of paracetamol which is highly reactive- if take 10-20 tablets will cause severe irreversible hepatocellular and renal tubular damage, nausea, vomiting, abdominal pain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Opioid examples

A

Weak- codeine
strong- morphine and fentanyl
Buphrenorphine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Opioid mechanism of action

A

M and U receptors agonists

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Opioids uses

A

analgesia
pain
diarrhoea

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Opioid side effects

A 
paralytic ileus
naursea 
vomiting
sedation
addiction
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Immunosuppressant examples

A

methotrexate, sulfasalazine, influximab, fituximab, adalimumab, corticosteroids, azathioprine, calcineurine inhibitors, mycophenolate mofeti

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Immunosuppressant mechanism of actions

A

many

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Methotrexate mechanism of action

A

folate antagonist, inhibits T cell activation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Infliximab mechanism of action

A

binds to soluble TNF alpha and inhibits binding

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Corticosteroids mechanism of action

A

prevent IL1 and IL6 production

17
Q

Immunosuppressant uses

A

RA, vasculitis, psoriasis, chrohns, UC, cancer, arthritis

18
Q

Immunosuppression side effects

A 
Cirrhosis
Pneumonitis
Myelonesuppression
Decreased appetite
headache, nausea vomiting
rash, tingling, itching
19
Q

Anticholinesterase examples

A

Neostigmine

Pyridostigmine

20
Q

Anticholinesterase mechanism of action

A

inhibition of cholinesterase’s

21
Q

Anticholinesterase uses

A

Myasthenia gravis

Pharmacology (13 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions