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Pharmacology > CNS drugs > Flashcards

CNS drugs Flashcards

1
Q

5HT3 receptor antagonist mechanism of action

A

Blocks the 5HT3 receptors
So serotonin cannot bind
So reduces GI motility and secretions

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2
Q

D2 receptor antagonist uses

A

Metacloperamide- GORD, ileus

Domperidone- lactation in breast feeding

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3
Q

Dementia drugs mechanism of action

A

Reversible acetyl cholinesterase inhibitor

Memantine- block current through NMDA channels

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4
Q

H1 receptor antagonist side effects

A

dry mouth, urinary retention, cardiac toxicity

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5
Q

Anti epileptic drugs mechanism of action

A

CYP450 inducer
Sodium channel blocker, binds during depolarisation, prolongs inactivation so cannot stimulates another action potential
So reduced probability of high abnormal spiking activity

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6
Q

Pure non selective monoamine uptake inhibitor examples

A

Venlafaxine

Fluoxetine

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7
Q

Anti epileptic drug examples

A

Carbamazepine
Lamotrigine
Phenytoin
Sodium valproate

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8
Q

Valproic acid uses

A

Anti convulsant

Bipolar mania

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9
Q

Muscarinic receptor antagonist example

A

Hyoscine Hydrobromide

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10
Q

5HT3 receptor antagonist side effects

A

Increase liver enzymes, long QT syndrome

Extra pyramidal effects

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12
Q

Typical antipsychotic uses

A

Sedation and tranquilisation

Antipsychotic

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13
Q

Anxiolytic uses

A

Anxiety

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14
Q

Tricyclic antidepressant side effects

A 
Sedation
Impairment of psychomotor performance
Tachycardia 
postural hypotension 
Constipation
Reduced seizure threshold
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15
Q

Muscarinic receptor antagonist uses

A

Motion sickness

Bowel obstruction

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16
Q

D2 receptor side effects

A

Galactorrhea
Dystonia and Parkinsonism
Sudden cardiac death

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17
Q

Atypical antipsychotic uses

A

Sedation
Tranquilisation
Anti psychotic

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18
Q

SSRI uses

A

Anxiety

Depression

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19
Q

Typical antipsychotic side effects

A

Extra pyramidal side effects- Parkinsonism
Dystonia, dyskinesia, neuroleptic, akathesis
Postural hypotension and weight gain

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20
Q

Anxiolytic side effects

A

psychomotor impairment, dry mouth and blurred vision

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21
Q

Anti obesity drug examples

A

Orlistat

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22
Q

Pure non selective monoamine uptake inhibitor uses

A

Second or third line for depression

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23
Q

Typical antipsychotic examples

A

Chlorpromazine

Haloperidol

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24
Q

SSRI mechanism of actions

A

Selective serotonin reuptake inhibitor

25
Q

D2 receptor antagonist examples

A

Metoclopramide

Domperidone

26
Q

Dementia drugs examples

A

Donepezil
Galantamine
Memantine

27
Q

Anti obesity drug mechanism of action

A

Inhibits gastric and pancreatic lipases

Triglycerides from the diet are not hydrolysed and are excreted unchanged

28
Q

H1 receptor antagonist uses

A

Motion sickness

Promethazine can be used for morning sickness

29
Q

Lithium side effects

A

Memory problems
Thirst, polyuria
Tremor
Hair loss

30
Q

Typical anstipsychotic mechanism of action

A

Dopamine receptor blocker, anticholinergic effects, anti histamine
D2 receptor antagonist

31
Q

5HT3 receptor antagonist example

A

Ondansetron

31
Q

SSRI examples

A

Setraline
Fluoxetine
Citalopram

33
Q

Anti obesity drug side effects

A

Oily spotting on underwear Flatulence
Urgent bowel movements
Fatty stools

34
Q

Anxiolytic mechanism if action

A

Exerts effect through a GABA-BDZ receptor complex
Acts as a full antagonist of BDZ receptor
Increases GABA

35
Q

Atypical antipsychotic side effects

A

Weight gain

Increased prolactin sedation

36
Q

SSRI side effects

A

Anorexia, mania, suicidal ideation, tremor

37
Q

D2 receptor antagonist mechanism of action

A

Increase ACH at muscarinic receptors in gut
Increase gastric emptying
Increase tone at LOS, increase tone and amplitude of gastric contractions
Decrease tone at pylorus so it opens
Increase peristalsis

38
Q

Lithium mechanism of action

A

Compete with magnesium and calcium ions

Acts as Neurotransmitter

39
Q

Pure non selective monoamine uptake inhibitor mechanism of action

A

SSRIs with noradrenaline uptake inhibition added

Low dose has serotonin action and high dose has noradrenaline action

41
Q

H1 receptor antagonist example

A

Cyclizine

42
Q

Pure non selective monoamine inhibitor side effects

A

Same as SSRIs and sleep disturbance, high blood pressure, dry mouth

43
Q

Atypical antipsychotic examples

A

Olanzapine
Risperidone
Quetiapine

44
Q

H1 receptor antagonist mechanism of action

A

Centrally acts on the vestibular nuclei, inhibits histaminergic signals from vestibular System to the chemoreceptor trigger zone in the medulla

45
Q

Anxiolytic examples

A

Benzodiazepines
Diazepam
Lorazepam

45
Q

Muscarinic receptor antagonist mechanism of action

A

Blocks Muscarinic ach receptors

Blocks in vestibular nuclei and chemoreceptors trigger zone and all over the body

46
Q

Tricyclic antidepressant mechanism of action

A

Inhibits noradrenaline uptake so causes sympathomimetic effect
Muscarinic cholinoreceptor blockage so anticholinergic effect
Alpha 1 adrenoreceptor blockage so symaptholytic effect

47
Q

Parkinson drugs

A

Dopamine precursors
Ropinirole, Levodopa, Entacapone, amantadine, procyclidine, apomorphine, rasaligine, selegilne
COMT and MOTypeB inhibitors

48
Q

5HT3 receptor antagonist uses

A

Sickness

48
Q

Tricyclics antidepressant uses

A

Depression

Not used much anymore

50
Q

Tricyclic antidepressant examples

A

Imipramine

Lofepramine

51
Q

Lithium uses

A

Prophylaxis of mania and depression
Augmentation of antideppressant
Decrease suicidality
Bipolar

52
Q

Atypical antipsychotic mechanism of action

A

D2 receptor antagonist

Less side effects than typical

52
Q

Valproic acid mechanism of action

A

Increases GABA and blocks voltage gated sodium channels

53
Q

Muscarinic receptor antagonist side effects

A

Dry mouth and constipation
Sedation
Glaucoma
Memory problems

53
Q

Anti epileptic uses

A

Epilepsy

55
Q

Anti epileptic side effects

A

Dizziness

Drowsiness, rashes, tetrogenic, CNS sedation ataxia

Pharmacology (13 decks)

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