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Pharmacology > Immune system > Flashcards

Immune system Flashcards

1
Q

Chemotherapy examples

A

Alkylating agents
Antimetabolites
Spindle poisons

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2
Q

Alkylating agent examples

A

Cisplatin

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3
Q

Antimetabolite examples

A

Methotrexate, 5 Fluoracil

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4
Q

Spindle poisons example

A

vincristine, vinblastine (vinca alkaloids), paclitaxel (taxanes)

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5
Q

Alkylating agents mechanism of action

A

Target DNA synthesis

Form covalent bonds with DNA nucleosides disrupting the structure and preventing replication

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6
Q

Antimetabolite mechanism of action

A

Folate antagonist

inhibits T cell cycle

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7
Q

Spindle fibre mechanism of action

A

Inhibits tubular polymerisation

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8
Q

Chemotherapy uses

A

Cancer

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9
Q

Chemotherapy side effects

A

Acute renal failure,
GI perforation
Vomiting, hair falls out, skin toxicity, Mucositis
drug interactions

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10
Q

Antiproliferative immunosuppressant examples

A

Azithoprine
Cyclophosphamide
Mycophenolate

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11
Q

Antiproliferative immunosuppressant mechanism of action

A

Inhibits the synthesis of DNA, RNA, and proteins by antagonising purine metabolism

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12
Q

Antiproliferative immunosuppressant uses

A

Stop transplant rejection
RA
SLE

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13
Q

Antiproliferative immunosuppressant side effects

A

Viral infection
Nausea
Vomiting, Diarrhea
Pain or burning

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14
Q

Calcineurin inhibitors mechanism of action

A

Active Helper T cells and prevent production of IL-2 via calcineuin inhibition

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15
Q

Calcineurin inhibitor uses

A

Dermatitis and psoriasis

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16
Q

Calcineurin inhibitor side effects

A 
Hypotension
Tremor
GI distrubance
Nephrotoxicity, hepatotoxicity
Headaches
17
Q

Local anaesthetic examples

A

Bupivacaine
Lidocaine
Ropivacaine

18
Q

Local anaesthetic mechanism of action

A

Inhibits excitation of nerve endings or by blocking conduction of peripheral nerves

19
Q

Local anaesthetic uses

A

Numb feeling in part of the body

20
Q

Local anaesthetic side effects

A

Drowsiness, dizziness, vomiting, hot or cold, confusion

Pharmacology (13 decks)

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