Lipid lowering drugs

Question 1

Statin examples

Answer 1

Atovastatin

Simvastatin

Question 2

Statin mechanism of action

Answer 2

Competitively inhibits HMG-CoA reductase

Question 3

Statin uses

Answer 3

Hyperlipidemia

anti inflammatory

Question 4

Statin side effects

Answer 4

transient serum transaminase elevation 
Myalgia - Diffuse muscle pain
Rhambdomyoloysis
GI symptoms
grapefruit reacts to give more side effects

Question 5

Fibrates examples

Answer 5

Fenofibrate

Question 6

Fibrate mechanism of action

Answer 6

PPAP-alpha activator

Question 7

Fibrate uses

Answer 7

Hyperlipidemia with low HDL that dont response to Na

Hypertirglyceridemia

Question 8

Fibrate side effects

Answer 8

GI upset
Cholelithiasis
Myosititis
abnormal LFTs
warfarin potentiation
renal issues

Question 9

Cholesterol absorption inhibitor examples

Answer 9

Ezetimibe

Question 10

Cholesterol absorption inhibitor mechanism of action

Answer 10

NPC1L1 transpoter inhibitor on brush border of small intestine
decreases absorption of the guy

Question 11

Cholesterol absorption inhibitor uses

Answer 11

Hyperlipidemia

Question 12

Cholesterol absorption inhibitor side effects

Answer 12

Head ache
GI upset
well tolerated usually

Question 13

Nicotinic acid example

Answer 13

Niacin

Question 14

Nicotinic acid mechanism of action

Answer 14

Inhibition of diacylglycerol acetyltranferase 2

Question 15

Nicotinic acid uses

Answer 15

Hyperlipidemia

Question 16

Nicotinic acid side effects

Answer 16

Flushing
Headaches itching
GI disturbance

Question 17

PC5K9 Inhibitor examples

Answer 17

Alirocumab

Evolocumab

Question 18

PC5K9 Inhibitor mechanism of action

Answer 18

monoclonal antibodies that inhibit the PC5K9 enzyme

Question 19

PC5K9 Inhibitor uses

Answer 19

lowers LDL levels

Question 20

PC5K9 Inhibitor side effects

Answer 20

infection site swelling or rash
limb pain
fatigue