MS Flashcards
what
chronic + progressive condition which involves demyelination in CNS
inflammatin + immune cells damage myelin
when does it typically present
young adults
more common in what sex
females
how does pregnancy affect symptoms
improve
key expression
disseminated in time and space
associations
multiple genes EBV low vitD smoking obesity
features: eye movement abnormalities
6th nerve palsy
- internuclear ophthalmoplegia
- conjugate lateral gaze disorder
features: focal weakness
bells palsy
horner’s
limb paralysis
incontinence
features: focal sensory symptoms
trigeminal neuralgia
numbness
paraeshesia
Lhermitte’s sign
Lhermitte’s sign
electric shock sensation travels down spin and into limbs when flexing neck
caused by stretching demyelinated dorsal column
features: ataxia
problem with coodrinated movement
sensory - loss proprioceptive sense
or
cerebellar - problem with cerebellum coordinating movements
disease patterns
relapsing remitting
secondary progressive
primary progressive
disease patterns: relapsing remitting
most common at initial Dx
episodes of disease followed by recovery
acive
non-active
worsening
not worsening
disease patterns: secondary progressive
was RR at first but now progressive worsening of Sx with incomplete remissions
symptoms become more and more permanent
disease patterns: primary progressive
worsening of disease and symptoms from point of Dx w/o initial RR
