lambort eaten mysathenic syndrome Flashcards
1
Q
typically occurs in patients with
A
SCLC
2
Q
pathphysiology
A
antibodies are produced which target voltage-gated calcium channels of SCLC
these antibodies also target and damage voltage gated calcium channels of NMJ
3
Q
presentation
A
symptoms develop slowly
proximal muscle weakness esp legs
diploplia
ptosis
dysphadia
autonomic dysfunction
- dry mouth
- blurred vision
- dizziness
4
Q
OE
A
reduced tendon reflexes
post-tetanic potentiation
5
Q
Mx
A
diagnose and treat underlying cancer
amifampridine
6
Q
Amifampridine
A
allows more Ach to be released in NMJ
works by blocking voltage gated potassium channels which prolongs depolarisation of cells and assists Ca channels carry out action
