Guillian-Barre Syndrome Flashcards
1
Q
what
A
acute paralytic polyneuropath
causes acute, symmetrical ascending weakness
2
Q
tigger
A
infection
- campylobacter jejuno
- CMV
- EBV
3
Q
pathophysiology
A
molecular mimicry
B cells create antibodies aginst pathogen antigens. Antibodeis also match myelin sheath proteins
4
Q
features
A
symmetrical ascending weakness
reduced reflexes
may be peripheral sensory loss or neuropathic pain
can progress to cranial nerves and cause facial weakness
5
Q
clinical course
A
Sx usually start 4wks after preceding infection
Sx peak within 2-4wks
recovery period can last months to years
6
Q
Diagnosis
A
Brighton critera
nerve conduction studies
LP
7
Q
LP shows
A
raised protein
normal cell count
normal Glc
8
Q
Mx
A
IV Ig (or plasma exchange)
VTE prophylaxis
9
Q
prognosis
A
80% full recovery
15% left with neuro disability
5% die
