MORPHOLOGIC ABNORMALITIES OF LEUKOCYTES Flashcards
Autosomal dominant disorder
characterized by decreased
nuclear segmentation and
distinctive coarse chromatin
clumping pattern.
PELGER-HUET ANOMALY
- the characteristic
spectacle-like (“pince-nez”)
morphology with the nuclei
attached by a thin filament
PELGER-HUET ANOMALY
PELGER-HUET ANOMALY:
- the characteristic
spectacle-like (“_____”)
morphology with the nuclei
attached by a thin filament
pince-nez
T or F
In PHA, neutrophils are functioning normally
T
Also known as “Acquired Pelger-Huet”
Pseudo-Pelger Huet Anomaly
Pseudo-Pelger Huet Anomaly:
Observed in patients with hematologic malignancy:
Acute Myeloid Leukemia
MDS
More than 5 nuclear lobes present
HYPERSEGMENTATION OF NEUTROPHILS
HYPERSEGMENTATION OF NEUTROPHILS:
associated with:
Megaloblastic anemia
Myelodysplastic syndrome
Causes of Megaloblastic anemia
Vitamin B12 deficiency
Folic acid deficiency
Pernicious anemia
Granulocytes have dark staining
granules (Reilly bodies) NOT
related to infection
ALDER-REILLY ANOMALY
ALDER-REILLY ANOMALY:
Root cause:
Incomplete degradation of mucopolysaccharides
T or F
In Alder-Reilly Anomaly, Neutrophils are functioning normally; can also be present in monocytes and lymphocytes
T
ALDER-REILLY ANOMALY:
Associated with:
Hurler’s syndrome
Hunter syndrome
Sanfilippo syndrome
Rod-like bodies representing aggregated
primary granules
AUER RODS
AUER RODS:
Peroxidase:
+
AUER RODS:
Observed in blast cells present in ___, especially in ________
AML
Acute Promyelocytic Leukemia
Bundles of Auer rods
Faggot cells
There is disordered production of myosin heavy
chain type II-A, which affects megakaryocyte maturation and platelet fragmentation when shedding from megakaryocytes
MAY-HEGGLIN ANOMALY
MAY-HEGGLIN ANOMALY:
Triad:
Dohle-like inclusion bodies
Thrombocytopenia
Giant platelets
