LYMPHOPROLIFERATIVE DISORDERS

Question 1

T or F
In LYMPHOPROLIFERATIVE DISORDERS, they are classified by WHO thru their biological features and not the anatomical distribution

Answer 1

T

Question 2

MATURE B-CELL NEOPLASMS:
Most common leukemia in adults in Western countries

Answer 2

Chronic Lymphocytic Leukemia (CLL

Question 3

MATURE B-CELL NEOPLASMS:
Chronic Lymphocytic Leukemia (CLL):
Medial age of diagnosis is approximately ____ years, with a slight ____
preponderance

Answer 3

72
male

Question 4

Accumulation of small lymphoid cells in the Bone Marrow, peripheral blood and lymphoid organs

Answer 4

Chronic Lymphocytic Leukemia (CLL)

Question 5

Chronic Lymphocytic Leukemia (CLL):
Lab detection:
- Small lymphocytes “_______” appearance, scant cytoplasm, ______ nucleoli
- Prolymphocytes are present up to ___ %
- Numerous _______ cells or ______ cells on blood smear

Answer 5

soccer ball
absent
55%
Smudge or Basket

Question 6

MATURE B-CELL NEOPLASMS:
Median age of diagnosis is approximately 50 years, with a slight male preponderance

Answer 6

Hairy Cell Leukemia

Question 7

MATURE B-CELL NEOPLASMS:
Hairy Cell Leukemia
Median age of diagnosis is approximately ____ years, with a slight ___ preponderance

Answer 7

50
male

Question 8

Small lymphocytes with abundant cytoplasm and hairy cytoplasmic projection

Answer 8

Hairy Cell Leukemia

Question 9

Hairy Cell Leukemia:
Leukemic cells are found primarily in ________

Answer 9

bone marrow and spleen

Question 10

Hairy Cell Leukemia:
Lab Detection:

Answer 10

Cytochemical Stain – Tatrate resistant Acid Phosphatase
Annexin A
Surface CD19, CD20, CD23

Question 11

Hairy Cell Leukemia:
Surface CD____

Answer 11

CD19, CD20, CD23

Question 12

Protein expression that can be used as specific marker to HCL

Answer 12

Annexin A

Question 13

hairy cells show ______ cytoplasmic staining

Answer 13

red granular

Question 14

Aggressive cancer of mature B cells associated with a fulminant clinical presentation

Answer 14

Burkitt Lymphoma

Question 15

Burkitt Lymphoma has three subtypes:

Answer 15

endemic, sporadic and HIV associated

Question 16

Medium-sized lymphoid cells which have deeply basophilic cytoplasm; highly vacuolated

Answer 16

Burkitt Lymphoma

Question 17

Burkitt Lymphoma:
Bone marrow and lymph node biopsies may show a classic “______” appearance on LPF

Answer 17

starry sky

Question 18

MATURE B-CELL NEOPLASM:
Median age at diagnosis is 68 years, and males are affected more than females

Answer 18

Mantle Cell Lymphoma

Question 19

Mantle Cell Lymphoma:
Median age at diagnosis is ___ years, and males are affected ____ than females

Answer 19

68
more

Question 20

Mantle Cell Lymphoma:
Accurate diagnosis requires demonstration of either _____ or overexpression of ______

Answer 20

t(11;14)
cyclin D1

Question 21

Most common form (25-30% of cases) of Non-Hodgkin’s Lymphoma

Answer 21

Diffuse Large B-cell Lymphoma

Question 22

Clinical presentation is a rapidly expanding, painless lymphadenopathy in one or more sites

Answer 22

Diffuse Large B-cell Lymphoma

Question 23

Diffuse Large B-cell Lymphoma
Lab Findings:
- ____ lymphoid cells with ____ histologic growth pattern
Surface Markers:

Answer 23

Large, diffuse
CD5, CD10, CD30

Question 24

MATURE T-CELL LYMPHOMA
Most common type of cutaneous lymphoma (60-70% or cases)

Answer 24

Mycosis Fungoides

Question 25

Small lymphoid cells that have predilection to epidermis and dermis (tumor-like lesions)

Answer 25

Mycosis Fungoides

Question 26

T or F in Mycosis Fungiodes, dissemination to lymph nodes, organs, and blood in later stages

Answer 26

T

Question 27

Malignant T cells (_______) have cerebriform, folded nucleus, variably condensed chromatin

Answer 27

Sezary cell

Question 28

Aggressive lymphoma with leukemic presentation (peripheral blood involvement)

Answer 28

Sezary Syndrome

Question 29

Characterized by erythroderma and generalized lymphadenopathy

Answer 29

Sezary Syndrome

Question 30

An absolute Sezary cell count greater than ______/L is Required to make the Sezary Syndrome diagnosis

Answer 30

1x10^9/L

Question 31

Malignant disorders of terminally differentiated B cells

Answer 31

PLASMA CELL NEOPLASMS

Question 32

Essential characteristic is the ability of the plasma cells to secrete monoclonal immunoglobulin (Ig)

Answer 32

PLASMA CELL NEOPLASMS

Question 33

Benign monoclonal proliferation of plasma cells; represents precursor state for myeloma

Answer 33

Monoclonal Gammopathy of Undetermined Significance (MGUS)

Question 34

T or F Monoclonal Gammopathy of Undetermined Significance (MGUS), there is presence of end organ damage

Answer 34

F Absence

Question 35

Characterized by monoclonal proliferation of plasma cells in the BM

Answer 35

Plasma cell Myeloma (MM)

Question 36

Plasma cell Myeloma (MM): Clinical findings:

Answer 36

bone lesions and hypercalcemia

Question 37

Plasma cell Myeloma (MM): Lab findings: - Monoclonal gammopathy (SPE) /_______/ paraproteins - ______ proteins in urine - Presence of _____ cells, ____cell / ______ cells in peripheral smear - malignant plasma cells express high levels of CD___ and CD_____

Answer 37

M protein Bence-Jones flame, mott , grape 38 and 138

Question 38

Bence jones precipitate between ____ and redissolves at _____

Answer 38

0-60℃ 100℃

Question 39

Low-grade lymphoplasmacytic lymphoma associated with aberrant secretion of IgM

Answer 39

Waldenstrom’s Macroglobulinemia (WM)

Question 40

High levels of IgM can result in a ________

Answer 40

hyperviscosity syndrome

Question 41

Waldenstrom’s Macroglobulinemia (WM): Involves a somatic mutation in the myeloid differentiation factor ________ gene

Answer 41

88 (MYD88)

Question 42

MM= due to monoclonal ____ WM= due to monoclonal ____

Answer 42

IgG IgM

Question 43

Characterized by the presence of Reed- Sternberg Cells

Answer 43

HODGKIN’S LYMPHOMA

Question 44

“Owl's eye” appearance

Answer 44

HODGKIN’S LYMPHOMA

Question 45

Has abundant cytoplasm & bilobed nucleus with prominent eosinophilic nucleoli

Answer 45

HODGKIN’S LYMPHOMA

Question 46

T or F Reed-Sternberg cells are B-cell origin and almost never found in peripheral blood

Answer 46

T

Question 47

HODGKIN’S LYMPHOMA: Surface markers:

Answer 47

CD15 and CD30

Question 48

L&H cells are large with scant cytoplasm and a folded single nucleus

Answer 48

Lymphocyte-predominant HL

Question 49

They are labeled “popcorn” cells because of their distinct morphology

Answer 49

Lymphocyte-predominant HL