LYMPHOPROLIFERATIVE DISORDERS Flashcards
T or F
In LYMPHOPROLIFERATIVE DISORDERS, they are classified by WHO thru their biological features and not the anatomical distribution
T
MATURE B-CELL NEOPLASMS:
Most common leukemia in adults in Western countries
Chronic Lymphocytic Leukemia (CLL
MATURE B-CELL NEOPLASMS:
Chronic Lymphocytic Leukemia (CLL):
Medial age of diagnosis is approximately ____ years, with a slight ____
preponderance
72
male
Accumulation of small lymphoid cells in the Bone Marrow, peripheral blood and lymphoid organs
Chronic Lymphocytic Leukemia (CLL)
Chronic Lymphocytic Leukemia (CLL):
Lab detection:
- Small lymphocytes “_______” appearance, scant cytoplasm, ______ nucleoli
- Prolymphocytes are present up to ___ %
- Numerous _______ cells or ______ cells on blood smear
soccer ball
absent
55%
Smudge or Basket
MATURE B-CELL NEOPLASMS:
Median age of diagnosis is approximately 50 years, with a slight male preponderance
Hairy Cell Leukemia
MATURE B-CELL NEOPLASMS:
Hairy Cell Leukemia
Median age of diagnosis is approximately ____ years, with a slight ___ preponderance
50
male
Small lymphocytes with abundant cytoplasm and hairy cytoplasmic projection
Hairy Cell Leukemia
Hairy Cell Leukemia:
Leukemic cells are found primarily in ________
bone marrow and spleen
Hairy Cell Leukemia:
Lab Detection:
Cytochemical Stain – Tatrate resistant Acid Phosphatase
Annexin A
Surface CD19, CD20, CD23
Hairy Cell Leukemia:
Surface CD____
CD19, CD20, CD23
Protein expression that can be used as specific marker to HCL
Annexin A
hairy cells show ______ cytoplasmic staining
red granular
Aggressive cancer of mature B cells associated with a fulminant clinical presentation
Burkitt Lymphoma
Burkitt Lymphoma has three subtypes:
endemic, sporadic and HIV associated
Medium-sized lymphoid cells which have deeply basophilic cytoplasm; highly vacuolated
Burkitt Lymphoma
Burkitt Lymphoma:
Bone marrow and lymph node biopsies may show a classic “______” appearance on LPF
starry sky
MATURE B-CELL NEOPLASM:
Median age at diagnosis is 68 years, and males are affected more than females
Mantle Cell Lymphoma
Mantle Cell Lymphoma:
Median age at diagnosis is ___ years, and males are affected ____ than females
68
more
Mantle Cell Lymphoma:
Accurate diagnosis requires demonstration of either _____ or overexpression of ______
t(11;14)
cyclin D1
Most common form (25-30% of cases) of Non-Hodgkin’s Lymphoma
Diffuse Large B-cell Lymphoma
Clinical presentation is a rapidly expanding, painless lymphadenopathy in one or more sites
Diffuse Large B-cell Lymphoma
Diffuse Large B-cell Lymphoma
Lab Findings:
- ____ lymphoid cells with ____ histologic growth pattern
Surface Markers:
Large, diffuse
CD5, CD10, CD30
MATURE T-CELL LYMPHOMA
Most common type of cutaneous lymphoma (60-70% or cases)
Mycosis Fungoides
Small lymphoid cells that have predilection to epidermis and dermis (tumor-like lesions)
Mycosis Fungoides
T or F
in Mycosis Fungiodes, dissemination to lymph nodes, organs, and blood in later stages
T
Malignant T cells (_______) have cerebriform, folded nucleus, variably condensed chromatin
Sezary cell
Aggressive lymphoma with leukemic presentation (peripheral blood involvement)
Sezary Syndrome
Characterized by erythroderma and generalized lymphadenopathy
Sezary Syndrome
An absolute Sezary cell count greater than ______/L is Required to make the Sezary Syndrome diagnosis
1x10^9/L
Malignant disorders of terminally differentiated B cells
PLASMA CELL NEOPLASMS
Essential characteristic is the ability of the plasma cells to secrete monoclonal immunoglobulin (Ig)
PLASMA CELL NEOPLASMS
Benign monoclonal proliferation of plasma cells; represents precursor state for myeloma
Monoclonal Gammopathy of Undetermined Significance (MGUS)
T or F
Monoclonal Gammopathy of Undetermined Significance (MGUS), there is presence of end organ damage
F
Absence
Characterized by monoclonal proliferation of plasma cells in the BM
Plasma cell Myeloma (MM)
Plasma cell Myeloma (MM):
Clinical findings:
bone lesions and hypercalcemia
Plasma cell Myeloma (MM):
Lab findings:
- Monoclonal gammopathy (SPE) /_______/ paraproteins
- ______ proteins in urine
- Presence of _____ cells, ____cell / ______ cells in peripheral smear
- malignant plasma cells express high levels of CD___ and CD_____
M protein
Bence-Jones
flame, mott , grape
38 and 138
Bence jones precipitate between ____ and redissolves at _____
0-60℃
100℃
Low-grade lymphoplasmacytic lymphoma associated with aberrant secretion of IgM
Waldenstrom’s Macroglobulinemia (WM)
High levels of IgM can result in a ________
hyperviscosity syndrome
Waldenstrom’s Macroglobulinemia (WM):
Involves a somatic mutation in the myeloid differentiation factor ________ gene
88 (MYD88)
MM= due to monoclonal ____
WM= due to monoclonal ____
IgG
IgM
Characterized by the presence of Reed- Sternberg Cells
HODGKIN’S LYMPHOMA
“Owl’s eye” appearance
HODGKIN’S LYMPHOMA
Has abundant cytoplasm & bilobed nucleus with
prominent eosinophilic nucleoli
HODGKIN’S LYMPHOMA
T or F
Reed-Sternberg cells are B-cell origin and almost never found in peripheral blood
T
HODGKIN’S LYMPHOMA:
Surface markers:
CD15 and CD30
L&H cells are large with scant cytoplasm and a
folded single nucleus
Lymphocyte-predominant HL
They are labeled “popcorn” cells because of
their distinct morphology
Lymphocyte-predominant HL
