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Hema 1 Part 2 > LYMPHOPROLIFERATIVE DISORDERS > Flashcards

LYMPHOPROLIFERATIVE DISORDERS Flashcards

1
Q

T or F
In LYMPHOPROLIFERATIVE DISORDERS, they are classified by WHO thru their biological features and not the anatomical distribution

A

T

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2
Q

MATURE B-CELL NEOPLASMS:
Most common leukemia in adults in Western countries

A

Chronic Lymphocytic Leukemia (CLL

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3
Q

MATURE B-CELL NEOPLASMS:
Chronic Lymphocytic Leukemia (CLL):
Medial age of diagnosis is approximately ____ years, with a slight ____
preponderance

A

72
male

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4
Q

Accumulation of small lymphoid cells in the Bone Marrow, peripheral blood and lymphoid organs

A

Chronic Lymphocytic Leukemia (CLL)

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5
Q

Chronic Lymphocytic Leukemia (CLL):
Lab detection:
- Small lymphocytes “_______” appearance, scant cytoplasm, ______ nucleoli
- Prolymphocytes are present up to ___ %
- Numerous _______ cells or ______ cells on blood smear

A

soccer ball
absent
55%
Smudge or Basket

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6
Q

MATURE B-CELL NEOPLASMS:
Median age of diagnosis is approximately 50 years, with a slight male preponderance

A

Hairy Cell Leukemia

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7
Q

MATURE B-CELL NEOPLASMS:
Hairy Cell Leukemia
Median age of diagnosis is approximately ____ years, with a slight ___ preponderance

A

50
male

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8
Q

Small lymphocytes with abundant cytoplasm and hairy cytoplasmic projection

A

Hairy Cell Leukemia

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9
Q

Hairy Cell Leukemia:
Leukemic cells are found primarily in ________

A

bone marrow and spleen

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10
Q

Hairy Cell Leukemia:
Lab Detection:

A

Cytochemical Stain – Tatrate resistant Acid Phosphatase
Annexin A
Surface CD19, CD20, CD23

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11
Q

Hairy Cell Leukemia:
Surface CD____

A

CD19, CD20, CD23

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12
Q

Protein expression that can be used as specific marker to HCL

A

Annexin A

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13
Q

hairy cells show ______ cytoplasmic staining

A

red granular

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14
Q

Aggressive cancer of mature B cells associated with a fulminant clinical presentation

A

Burkitt Lymphoma

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15
Q

Burkitt Lymphoma has three subtypes:

A

endemic, sporadic and HIV associated

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16
Q

Medium-sized lymphoid cells which have deeply basophilic cytoplasm; highly vacuolated

A

Burkitt Lymphoma

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17
Q

Burkitt Lymphoma:
Bone marrow and lymph node biopsies may show a classic “______” appearance on LPF

A

starry sky

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18
Q

MATURE B-CELL NEOPLASM:
Median age at diagnosis is 68 years, and males are affected more than females

A

Mantle Cell Lymphoma

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19
Q

Mantle Cell Lymphoma:
Median age at diagnosis is ___ years, and males are affected ____ than females

A

68
more

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20
Q

Mantle Cell Lymphoma:
Accurate diagnosis requires demonstration of either _____ or overexpression of ______

A

t(11;14)
cyclin D1

21
Q

Most common form (25-30% of cases) of Non-Hodgkin’s Lymphoma

A

Diffuse Large B-cell Lymphoma

22
Q

Clinical presentation is a rapidly expanding, painless lymphadenopathy in one or more sites

A

Diffuse Large B-cell Lymphoma

23
Q

Diffuse Large B-cell Lymphoma
Lab Findings:
- ____ lymphoid cells with ____ histologic growth pattern
Surface Markers:

A

Large, diffuse
CD5, CD10, CD30

24
Q

MATURE T-CELL LYMPHOMA
Most common type of cutaneous lymphoma (60-70% or cases)

A

Mycosis Fungoides

25
Q

Small lymphoid cells that have predilection to epidermis and dermis (tumor-like lesions)

A

Mycosis Fungoides

26
Q

T or F
in Mycosis Fungiodes, dissemination to lymph nodes, organs, and blood in later stages

A

T

27
Q

Malignant T cells (_______) have cerebriform, folded nucleus, variably condensed chromatin

A

Sezary cell

28
Q

Aggressive lymphoma with leukemic presentation (peripheral blood involvement)

A

Sezary Syndrome

29
Q

Characterized by erythroderma and generalized lymphadenopathy

A

Sezary Syndrome

30
Q

An absolute Sezary cell count greater than ______/L is Required to make the Sezary Syndrome diagnosis

A

1x10^9/L

31
Q

Malignant disorders of terminally differentiated B cells

A

PLASMA CELL NEOPLASMS

32
Q

Essential characteristic is the ability of the plasma cells to secrete monoclonal immunoglobulin (Ig)

A

PLASMA CELL NEOPLASMS

33
Q

Benign monoclonal proliferation of plasma cells; represents precursor state for myeloma

A

Monoclonal Gammopathy of Undetermined Significance (MGUS)

34
Q

T or F
Monoclonal Gammopathy of Undetermined Significance (MGUS), there is presence of end organ damage

A

F
Absence

35
Q

Characterized by monoclonal proliferation of plasma cells in the BM

A

Plasma cell Myeloma (MM)

36
Q

Plasma cell Myeloma (MM):
Clinical findings:

A

bone lesions and hypercalcemia

37
Q

Plasma cell Myeloma (MM):
Lab findings:
- Monoclonal gammopathy (SPE) /_______/ paraproteins
- ______ proteins in urine
- Presence of _____ cells, ____cell / ______ cells in peripheral smear
- malignant plasma cells express high levels of CD___ and CD_____

A

M protein
Bence-Jones
flame, mott , grape
38 and 138

38
Q

Bence jones precipitate between ____ and redissolves at _____

A

0-60℃
100℃

39
Q

Low-grade lymphoplasmacytic lymphoma associated with aberrant secretion of IgM

A

Waldenstrom’s Macroglobulinemia (WM)

40
Q

High levels of IgM can result in a ________

A

hyperviscosity syndrome

41
Q

Waldenstrom’s Macroglobulinemia (WM):
Involves a somatic mutation in the myeloid differentiation factor ________ gene

A

88 (MYD88)

42
Q

MM= due to monoclonal ____
WM= due to monoclonal ____

A

IgG
IgM

43
Q

Characterized by the presence of Reed- Sternberg Cells

A

HODGKIN’S LYMPHOMA

44
Q

“Owl’s eye” appearance

A

HODGKIN’S LYMPHOMA

45
Q

Has abundant cytoplasm & bilobed nucleus with
prominent eosinophilic nucleoli

A

HODGKIN’S LYMPHOMA

46
Q

T or F
Reed-Sternberg cells are B-cell origin and almost never found in peripheral blood

A

T

47
Q

HODGKIN’S LYMPHOMA:
Surface markers:

A

CD15 and CD30

48
Q

L&H cells are large with scant cytoplasm and a
folded single nucleus

A

Lymphocyte-predominant HL

49
Q

They are labeled “popcorn” cells because of
their distinct morphology

A

Lymphocyte-predominant HL

Hema 1 Part 2 (27 decks)

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