LYMPHOCYTE MORPHOLOGIC ABNORMALITIES

Question 1

Lymphocytes that exhibit REACTIVE
MORPHOLOGY

Answer 1

Downey Cell / Turk Cell

Question 2

Downey Cell / Turk Cell:
Also known as ______

Answer 2

Atypical, Reactive, Variant lymphocyte

Question 3

Occur as lymphocytes are stimulated
when interacting with antigens in
peripheral lymphoid organs

Answer 3

Downey Cell / Turk Cell

Question 4

Downey Cell / Turk Cell
Characteristics:
Cells have _____ cytoplasm
Cytoplasm may be _____ by surrounding RBCs

Answer 4

basophilic
indented

Question 5

Downey Cell / Turk Cell
Associated Dx:

Answer 5

Infectious Mononucleosis (Epstein Barr Virus)

Question 6

Caused by pressure in smear preparation; indicates nuclear fragility

Answer 6

Basket / Smudge Cell

Question 7

Basket / Smudge Cell
Increased numbers observed in ________

Answer 7

CLL (Chronic Lymphocytic Leukemia)

Question 8

Variant of plasma cell with irregular cytoplasmic projections (bright purplered in Wright’s stain)

Answer 8

Flame Cell

Question 9

These cells contain more immunoglobulin than normal plasma cells

Answer 9

Flame Cell

Question 10

Flame Cell
Associated with:

Answer 10

Multiple Myeloma

Question 11

Variant of plasma cell with round globules

Answer 11

Grape / Mott Cell / Rusell Bodies

Question 12

Grape / Mott Cell / Rusell Bodies
Associated with:

Answer 12

Multiple Myeloma

Question 13

Lymphocyte with convoluted, cerebriform nucleus (“brain-like nucleus”)

Answer 13

Sezary Cell

Question 14

Sezary Cell:
Associated with:

Answer 14

Cutaneous T-Cell Lymphoma
Sezary Syndrome
Mycoses Fungoides