FAB CLASSIFICATION OF AML

Question 1

AML, minimally differentiated

Answer 1

M0

Question 2

AML without maturation
No clear evidence of cellular maturation; Auer rods are absent

Answer 2

M1

Question 3

AML with maturation
Blasts comprise 90% of nonerythroid cells in Bone marrow
Closely aligned with the blasts of M0

Answer 3

M2

Question 4

Acute Promyelocytic Leukemia
Has at least 10% maturing cells of neutrophil lineage
Auer rods are often present

Answer 4

M3

Question 5

Acute Myelomonocytic Leukemia
Monoblasts and promonocytes constitute at least 20% of all Marrow cells
Also known as Naegelli Leukemia

Answer 5

M4

Question 6

M4 is also known as ______

Answer 6

Naegelli Leukemia

Question 7

Acute Myelomonocytic Leukemia with Eosinophilia

Answer 7

M4Eo

Question 8

Acute Monocytic Leukemia
Poorly differentiated

Answer 8

M5a

Question 9

Acute Monocytic Leukemia
Well differentiated

Answer 9

M5b

Question 10

Acute Erythroleukemia
80% or more of the bone marrow cells are erythroid; >30% are proerythroblasts
Also known as Di Guglielmo’s Syndrome

Answer 10

M6

Question 11

M6 is also known as _______

Answer 11

Di Guglielmo’s Syndrome

Question 12

Acute Megakaryocytic Leukemia
Blasts comprise at least 50% of megakaryocyte origin
Identified thru immunostaining using antibodies against vWF, gpIb, gpIIb/IIIa

Answer 12

M7