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Hema 1 Part 2 > ACUTE LEUKEMIA > Flashcards

ACUTE LEUKEMIA Flashcards

1
Q

Most common type of leukemia in adults, and the incidence increases with age

A

ACUTE MYELOID LEUKEMIA (AML)

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2
Q

ACUTE MYELOID LEUKEMIA (AML)
WBC count ranges from _______/L

A

1-200x109/L

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3
Q

ACUTE MYELOID LEUKEMIA (AML)
Myeloblasts are present in the peripheral blood in ___% of patients

A

90%

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4
Q

ACUTE MYELOID LEUKEMIA (AML)
Common Lab Findings:
A_____
Thrombocyto_____
Neutro_____
_________ with presence of ______ cells

A

Anemia
Thrombocytopenia
Neutropenia
Hypercellular Bone Marrow
blast cells

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5
Q

ACUTE MYELOID LEUKEMIA (AML)
Surface Markers present:

A

CD13
CD33
CD117

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6
Q

ACUTE MYELOID LEUKEMIA (AML)
Chemistry:
Hyper______
Hyper______
Hypo______

A

Hyperuricemia
Hyperphosphatemia
Hypocalcemia

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7
Q

Corresponds to acute myeloid leukemia with neutrophilic maturation; also known as core binding factor leukemia

A
  • AML with t(8:21)
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8
Q

Correspond to acute myelomonocytic leukemia with abnormal eosinophils: eosinophils are increased and have large basophilic granules

A

AML with inv(16)

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9
Q
  • Promyelocytes predominate in the Bone marrow;
  • Azurophillic granules are abundant
  • Multiple Auer rods are usually present
  • DIC (disseminated intravascular coagulation) is common
A

AML with t(15;17)

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10
Q

Rare leukemia (6% of AML cases) that presents with an increase in monoblasts and immature monoctyes

A

AML with t(9;11)

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11
Q
  • Associated with multilineage dysplasia and basophilia of marrow and blood
  • shows variable morphology and granulocytic and/or monocytic differentiation
A

AML with t(6;9)

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12
Q

Shows multilineage dysplasia, increased atypical megakaryocytes with monolobed or bilobed nuclei, and normal to increased platelet counts.

A

AML with inv(3)

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13
Q

Presenting as acute megakaryoblastic leukemia with hepatosplenomegaly
Acute leukemia of infants and young children, often reported in girls

A

AML with t(1;22)

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14
Q

25-75% of childhood leukemia (2-5 years of age)

A

ACUTE LYMPHOBLASTIC LEUKEMIA (ALL)

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15
Q

ACUTE LYMPHOBLASTIC LEUKEMIA (ALL)
25% of childhood ALL cases show the genetic abnormality; _____ derived from a B cell progenitor

A

t(12:21)

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16
Q

ACUTE LYMPHOBLASTIC LEUKEMIA (ALL):
Clinical findings:
Anemia
thrombocyto_____
neutro_____
lymphadenopathy
splenomegaly

A

thrombocytopenia
neutropenia

17
Q

ACUTE LYMPHOBLASTIC LEUKEMIA (ALL):
WHO classification:

A

B-cell ALL
T-cell ALL

18
Q

B-cell ALL Positive Markers

A

CD34, 22, 19, 10, TdT

19
Q

T-cell ALL Positive Markers

A

CD2, 3, 4, 5, 7, 9, TdT

Hema 1 Part 2 (27 decks)

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