LEUKEMIA Flashcards
Refers to the rapid, clonal proliferation in the bone marrow of lymphoid or myeloid progenitor cells known as lymphoblasts and myeloblasts
LEUKEMIA
CYTOGENETIC ABNORMALITIES IN LEUKEMIA:
Acute
Predominant Cell Type:
Precursors/ Blasts
CYTOGENETIC ABNORMALITIES IN LEUKEMIA:
Chronic
Predominant Cell Type:
Mature
CYTOGENETIC ABNORMALITIES IN LEUKEMIA:
Acute
Onset:
Sudden
CYTOGENETIC ABNORMALITIES IN LEUKEMIA:
Chronic
Onset:
Insidious
CYTOGENETIC ABNORMALITIES IN LEUKEMIA:
Acute
Symptoms:
Fever
Fatigue
Bleeding
CYTOGENETIC ABNORMALITIES IN LEUKEMIA:
Chronic
Symptoms:
Variable
Non-specific
CYTOGENETIC ABNORMALITIES IN LEUKEMIA:
Acute
Progression w/o treatment:
Rapid; weeks to month
CYTOGENETIC ABNORMALITIES IN LEUKEMIA:
Chronic
Progression w/o treatment:
Slow; months to years
Based on Cell morphology and cytochemical staining
French-American-British (FAB) System
Emphasized molecular and cytogenetic abnormalities
World Health Organization (WHO) System