MODY Flashcards
how strong is family history for MODY?
3 generation FH
what kind of inheritance is MODY?
autosomal dominant
age of onset of MODY?
<25
is MODY insulin dependent?
no
name the 3 methods that MODY can be acquired from?
glucokinase
HNF1 receptors
unknown
what happens in MODY from a glucokinase mutation?
glucokinase is less responsive to glucose so GLUT2 function altered = hyperglycaemia but because of normal insulin production loads is made so get hypo
what will OGTT of someone with a glucokinase mutation look like?
normal
what does the HbA1C of someone with a glucokinase mutation look like?
raised
when do glucokinase mutations arise in MODY?
onset at birth
how is a glucokinase mutation treated?
diet modifications, NO INSULIN
when do HNF1 mutations arise?
adolesence/young adult
is hyperglycaemia progressive in HNF1 or glucokinase mutations?
HNF1
how is HNF1 mutations treated?
1/3 diet, 1/3 OHA, 1/3 insulin
most common cause of MODY in UK?
HNF1 alpha
how can you tell the difference between MODY and diabetes via test
C peptide levels should be normal in MODY
