Mitochondria Flashcards

Understand the features, functions and structure of mitochondria

1
Q

Where are mitochondria located

A

cytosol

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2
Q

What is the function of mitochondria

A

make energy, role in apoptosis

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3
Q

TRUE or FALSE pyruvate enters mitochondria

A

TRUE

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4
Q

Where does the krebs cycle occur

A

mitochondria

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5
Q

Describe the structure of mitochondria

A

Double membrane, inner matrix with enzymes, inner membrane has cristae, highly compartmentalised

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6
Q

What does the mitochondrial matrix contain

A

enzymes of krebs cycle, ribosomes, mitochondrial DNA

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7
Q

describe the evolution of mitochondria

A

invagination of aerobic bacteria into an anaerobic cell,

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8
Q

Describe the structure of mitochondria from its evolution

A

retained prokaryotic membrane, outer membrane is similar to cytosolic membrane, carries own mitochondrial DNA

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9
Q

TRUE or FALSE -mitochondria are synthesised de novo

A

FALSE

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10
Q

how is mitochondrial DNA inherited

A

mother

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11
Q

Why is mitochondrial DNA inherited from the mother

A

oocytes contain more mitochondria than sperm, most sperm mitochondria dont transfer, paternal mitochondria are recognised as foreign

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12
Q

TRUE or FALSE, rates of mutation are higher in mitochondrial DNA than normal DNA

A

TRUE

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13
Q

Why is mitochondrial DNA mutation rate higher

A

no proof reading

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14
Q

What does mitochondrial DNA code for

A

rRNAs, tRNAs and some mitochondrial proteins

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15
Q

Where do ribosomes come from in mitochondria

A

nuclear genome and are transported in

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16
Q

Name two examples of mitochondrial disorders

A

MELAS and Leber hereditary optic nerve neuropathy

17
Q

what are the symptoms of MELAS

A

cognitive impairment, dementia, lactic acidosis and strokes

18
Q

What are the treatments for mitochondrial disorders

A

treat underlying neurological issues, avoid metabolic stress, gene therapy

19
Q

Describe the structure of chloroplasts

A

inner membrane, outer membrane, thylakoid membrane, stroma, contain own DNA

20
Q

What is the function of chloroplasts

A

Photosynthesis and carbon fixation

21
Q

What are the properties of peroxisomes

A

single membrane organelle, No DNA, contain enzymes which oxidase organic molecules