Minerals Flashcards

1
Q

Where is iron stored?

A

liver, spleen, bone marrow

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2
Q

Which form of iron is considered an acute phase reactant?

A

ferritin (storage form)

*store out of access to organisms that want it.

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3
Q

Which form of iron increases in iron deficiency anemia?

A

transferrin. transfers iron around body, looking for iron w/ high capacity, but low saturation

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4
Q

What are the 2 organs that mercury accumulates in?

A

kidney and brain

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5
Q

What are some symptoms of mercury poisoning?

A
abdominal pain
acrodynia: peeling of fingertips
peripheral neuropathy
tremor
excitability
insomnia
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6
Q

Where is mercury found?

A

Fish: shark, swordfish, tilefish, king mackerel (pregnant women avoid!!)
Old thermometers and batteries

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7
Q

Zinc is important for like everything! WHat are some especially important things?

A

Would Healing
Immune System
Zinc Finger Motifs-transcription
function of carbonic anhydrase and lactate dehydrogenase

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8
Q

What is a crazy rash that is seen w/ zinc deficiency?

A

acrodermatitis enteropathica

scaly plaques face or anus

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9
Q

Why is heme synthesis decreased w/ lead poisoning?

A

b/c lead inhibits ferrochelatase and ALA dehydratase

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10
Q

What is the treatment for lead poisoning?

A

EDTA and succimer (kids)

Severe cases: Dimercaprol

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11
Q

Give 2 histo features of lead poisoning.

A

Sideroblasts on peripheral smear. Causes sideroblastic anemia

basophilic stippling from aggregates of rRNA (lead inhibits rRNA degradation)

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12
Q

What can you see on X-ray for lead poisoning?

A

lead lines on long bones metaphyses…a part of cartilage remodeling
also see lead lines on teeth and gingivae (Burton lines)

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13
Q

Give the important symptoms of lead poisoning.

A
LEAD
Lead Lines
Encephalopathy and erythrocyte basophilic stippling
Abdominal Colic and Sideroblastic Anemia
Drops-wrist and foot.
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14
Q

What is the usual presentation of iron poisoning?

A

children who eat vitamins w/ lots of iron

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15
Q

What is the MOA for iron poisoning?

A

cell death due to per oxidation of membrane lipids and generation of free radicals

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16
Q

What are the initial symptoms of iron poisoning? After 72 hours? 2-8 weeks later?

A

Immediate:
gastric bleeding, hematemesis, abdominal pain

72 hours: metabolic acidosis

2-8 weeks: GI scarring–>obstruction

17
Q

What is used for OD of iron?

A

deferoxamine and dialysis