Lymphoma Flashcards
What differentiates Hodgkin from non-Hodgkin lymphoma?
Hodgkin: single group of lymph nodes, not extra nodal, better prognosis Reed-sternberg cells bimodal: young and old definite B symptoms associated w/ EBV
Non-Hodgkin: multiple nodal involvement, sometimes extranodal, usually B cells
variable age
few B symptoms
associated w/ HIV and autoimmune
What do Reed-sternberg cells look like?
owl eye
the more of these, the worse the prognosis
Describe the presentation of Hodgkin lymphoma?
painless nontender LAD mediastinal LAD B symptoms: low grade fever, night sweats, weight loss sometimes pruritis **wanna r/o TB
What are the different Hodgkin lymphoma subtypes?
Lymphocyte Predominant
Nodular Sclerosing
Mixed Cellularity
Lymphocyte-depleted
Describe the features of lymphocyte predominant?
L>RS
good prognosis
rare
younger males
Describe the features of nodular sclerosing Hogdkin lymphoma.
L>RS good prognosis most common subtype! Men=Women Biopsy: sclerosis, collagen formation, fibrosis
Describe the presentation of mixed cellularity hodgkin lymphoma.
RS & L
worse prognosis
2nd most common!
Describe the features of the lymphocyte-depleted hodgkin lymphoma.
RS>L
poor prognosis
Which CDs are present on Reed Sternberg cells?
2 owl eyes X 15 = 30
CD15
CD30
We are talking non-Hodgkin lymphoma. What are the B cell lymphomas?
Burkitt Lymphoma
Diffuse large B cell lymphoma–most common among adults and overall!
Follicular Lymphoma
Mantle Cell Lymphoma
Lymphoblastic lymphoma-most common in children!
Small lymphocytic lymphoma-lymphoma version of CLL
Marginal Cell MALToma
We are talking non-Hodgkin lymphoma. What are the T cell lymphomas?
Adult T cell lymphoma
Mycosis Fungoides/Sezary Syndrome
Intestinal T cell lymphoma-from long term celiac dx
What are the important features of Burkitt lymphoma?
young adults
t(8;14) translocation. Get more c-myc oncogene instead of heavy chain immunoglobulin
Starry sky on histo w/ lymphocytes as sky and macrophages as stars
Associated w/ EBV and jaw lesion in Africa. Sporadic form found in pelvis and abdomen
What are the important features of Diffuse large B cell lymphoma?
most common in adults and overall
seen in elderly
t(14;18) translocation in 30%. Get more BCL-2
What are the important features of follicular lymphoma?
t(14;18) get more BCL-2 instead of Ig heavy chain. Inhibits apoptosis.
waxing and waning LAD
What are the important features of Mantle Cell Lymphoma?
Older males
t(11;14) get more cyclin D1 and entry into S phase and less heavy chain Ig
CD5+
