Fat Soluble Vitamins

Question 1

What are some things that VIt A is used to treat?

Answer 1

acne
measles
AML subtype M3

Question 2

What happens w/ a deficiency of Vit A?

Answer 2

EYES
night blindness
dry scaly skin
corneal degeneration (keratomalacia)
xerophthalmia
bitot spots (silvery plaques) of conjunctiva

Question 3

What would toxicity of VIt A cause?

Answer 3

acute: N/V, blurred vision, vertigo
chronic: alopecia, dry skin
hepatomegaly
arthralgias
increased ICP (pseudo tumor cerebra)
teratogen!!

Question 4

What are the ways that you can get Vit D?

Answer 4

D2 (plants)

D3 (milk that is fortified, skin w/ UV)

Question 5

What is the storage form of VItD? Active form?

Answer 5

Storage form–liver. 25-OHD3 Calcidiol (measure)
–>25-hydroxylase
Active form–kidney. 1,25 OH D3. Calcitriol
–>1alpha hydroxylase

Question 6

Rickets and osteomalacia is due to a deficiency of what?

Answer 6

Vit D

Question 7

What are some causes of VIt D toxicity?

Answer 7

sarcoidosis and other granulomatous diseases. Epitheloid macrophages active Vit D.

Question 8

What are supplements that infants need ?

Answer 8

Need VIt D supplementation if only breastfed

Need injection Vit K after birth to avoid hemorrhagic disease of the newborn

Question 9

What is VitE?

Answer 9

tocopherol

antioxidant found in RBCs

Question 10

What does deficiency of Vit E look like?

Answer 10

similar to Vit B12 deficiency
hemolytic anemia
muscle weakness
ataxia (spinocerebellar tract demyelination)

Question 11

What is VIt K important for? How is it activated?

Answer 11

activated by intestinal flora

Disco started in 1972. Important for Protein C,S Factors 2, 7, 9, 10

Question 12

What are some drugs that can cause decreased Vit K?

Answer 12

Coumadin (anticoagulants)
anticonvulsants (phenytoin)
Antibiotics