Kidney-Glomerulus

Question 1

Give the breakdown of water % in the body.

Answer 1

60% body is water
2/3 of that (40%) is ICF
1/3 (20%) is ECF.
75% of ECF is interstitial
25% of ECF is plasma.

Question 2

What is the equation for renal clearance?

Answer 2

Cl=UV/P
u-urine conc’n
v-urine rate
p-plasma conc’n

Question 3

What is the equation for excretion rate?

Answer 3

UV

Question 4

Which substances estimate GFR?

Answer 4

Inulin and Creatinine (naturally made, but slightly secreted)
GFR=UxV/Px

Question 5

Which substance estimates renal plasma flow?

Answer 5

PAH. It is fully filtered and secreted. RPF=UpahV/Ppah

Question 6

What is the equation for filtration fraction? What is the normal %?

Answer 6

20%

FF=GFR/RPF

Question 7

What is the equation for filtered load?

Answer 7

GFR X Pconc’n

Question 8

What is the equation for reabsorption and secretion?

Answer 8

Reabsorbed=Filtered-Excreted

Secreted=Excreted-Filtered

Question 9

Describe glucose reabsorption?

Answer 9

PCT via Na+/glucose co-transporter

Question 10

When is the kidney’s ability to absorb glucose compromised?

Answer 10

glucose starts to spill into urine ~200mg/dl in plasma
around 350 mg/dl no more can be reabsorbed.
**seen in diabetes.

Question 11

Describe amino acid reabsorption in the kidney?

Answer 11

Na+ dependent at PCT. transporters for pos, neutral, and neg. charged AA.

Question 12

What is hartnup disease?

Answer 12

aut recessive
don't have neutral AA transporters in PCT and enterocytes
Decreased tryptophan in body, can't make niacin (Vit B3)
Get pellagra symptoms:
Dermatitis
Diarrhea
Dementia
Death