(Midterms) PCOG Lec Quiz 2 Flashcards
Secondary metabolites of carbohydrates along with gum and mucilages
Glycosides
Plant constituents that produce sugar as products of hydrolysis
Glycosides AKA?
Sugar Ethers
What is Glycoside composed of?
Glycone and Aglycone
These are regulatory, protective, and sanitary compounds
Glycosides
Sugar component of the Glycoside
Glycone
NON Sugar component of the Glycoside
Aglycone
Component of Glycoside that is the common denominator
Glycone
Component of Glycoside that is the basis of classification
Aglycone
Inactive component of Glycoside (No Pharmaceutical Action)
Glycone
Active component of Glycoside (Has Pharmaceutical Action)
Aglycone
What is Glycone composed of?
Sugar moiety
What is Aglycone composed of?
Lactone moiety and Steroid nucleus (CPPP: Cyclopentanoperhydrophenanthrene)
Other name of Aglycone
Genin
What test is used to determine Glycones?
Keller Kiliani Test
What test is used to determine Aglycones?
Liebermann-Burchard and Salkowski Test
What is the MOA of Cardiac Glycosides?
Inhibits the NA/K ATPase Pump
Where does the N/K ATPase Pump occur
Myocytes (Cardiac Muscles)
What is the goal of Cardiac Glycosides
To keep the Calcium in the cell
Two types of Cardiac Glycosides
Cardenolide and Bufadienolide
Which is more common in the 2 types of Cardiac Glycoside
Cardenolide
Which has optimum activity in the 2 types of Cardiac Glycosides
Cardenolide
Which is less common in the 2 types of Cardiac Glycoside
Bufadienolide
Which has less activity in the 2 types of Cardiac Glycosides
Bufadienolide
C,24,6 - membered lactone ring
Bufadienolide
C,23,5 - membered lactone ring
Cardenolide
Water Soluble: Digoxin or Digitoxin
Digoxin
Lipid Soluble: Digoxin or Digitoxin
Digitoxin
Less Toxic: Digoxin or Digitoxin
Digoxin
A digoxin common in hospitals for rapid initial dosing
Deslanoside
More Toxic: Digoxin or Digitoxin
Digitoxin
Absorbed: Digoxin or Digitoxin
Digitoxin
Common Brand name of Digoxin
Lanoxin