(Midterms) DDS Lec Quiz 1 Flashcards
solid dosage forms usually prepared with the aid of suitable pharmaceutical excipients.
Tablet
Tablets are prepared primarily by _______ with a limited number prepared by __________
Compression; Molding
Manufactured with tablet machines capable of exerting great pressure
Compressed Tablets
Shapes of compressed tablets are determined by the use of what?
Shaped punches and dies
Prepared on a large scale by tablet machinery or on a small scale by manually forcing dampened powder material into a mol
Molded Tablets
add the necessary bulk to a formulation to prepare tablets
Diluents/Fillers
Promote adhesion of the particles of the formulation
Binders/Adhesives
Promote breakup of the tablets after administration
Disintegrants
There are colorants and flavorants in the tablet
Miscellaneous adjunts
Antiadherents, glidants, or lubricants do the following:
- enhance the flow of the material into the tablet dies
- minimize wear of the punches and dies
- prevent fill material from sticking to the punches and dies
- produce tablets with a sheen
Prepared by subjecting the fill material to more than a single compression
Multiple Compressed Tablets
can be:
- multiple-layer tablet
- tablet within a tablet
may be coated with a colored or an uncolored sugar layer.
Sugarcoated Tablets
True or False:
Sugarcoated tablets are water soluble
True
How much percentage does sugarcoating add to the weight and bulk of the uncoated tablet
50%
Tablets that allow the patients to swallow smaller portions of it in divided dosage
Scored/Grooved Tablets
True or False:
I can break tablets that are not scored
False
Tablets that are not scored are not intended to be broken or cut as this could alter the tablet’s physical integrity
Compressed tablets coated with a thing layer of a polymer
Film-Coated Tablets
Prepared on a large scale by tablet machinery
Molded tablet
Steps in sugarcoating tablets
- Waterproofing and sealing
- Sub-coating
- Smoothing and final rounding
- Finishing and coloring
- Polishing
Advantages of Film-coated tablets over sugarcoated
- More durable
- Less bulky
- Less time-consuming to apply
Film-coating solutions may be:
Aqueous or nonaqueous
Capable of producing smooth, thin films reproducible under conventional coating conditions and applicable to a variety of tablet shapes
Film former
Make the appearance of the coated tablets handsome and distinctive
Opaquants and colorants
Providing water solubility or permeability to the film to ensure penetration by body fluids and therapeutic availability of the drug
Alloying substance
Produce flexibility and elasticity of the coating and thus provide durability
Plasticizer
Enhance spreadability of the film during application
Surfactant
Provide luster to the tablets without a separate polishing operation.
Glossant