Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Immuno/micro final > Middleton- herpes & papilloma > Flashcards

Middleton- herpes & papilloma Flashcards

1
Q

key characteristics of the Alphaherpesvirus

A
  • Variable host range
  • Short reproduction cycle
  • Rapid spread in culture
  • Efficient destruction of infected cells
  • Capacity to establish latency in sensory ganglia
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Herpes simplex virus type 1 & 2: what is its virus family, genome, virion

A
  • Alphaherpesvirus
  • dsDNA
  • enveloped
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

how is HSV-1 (herpes simplex virus type 1) spread?

A

oral-oral

oral-genital

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

T/F: HSV-1 infections are relatively rare among adults

A

False- almost 2/3rds are seropositive

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

HSV-2: how is it spread? how many adults are infected?

A

spread primarily thru sex:
-genital-genital

1 in 5 adults are infected

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Alphaherpesvirus primarily infect __________ or ______

A
  • epithelial cells in the skin

- mucosa

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

what are the symptoms of the Alphaherpesvirus?

A
  • flu-like
  • localized lesions

(only 1/3 of people show symptoms)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

how long do the initial symptoms of HSV-1 and HSV-2 last?

A

8-12 days

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

during the latency period, the alphaherpesvirus genome will do what?

A

circularizes and stays as an episome in the nucleus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

___________ are a common site of latent alphaherpesvirus infections

A

peripheral ganglia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

what can trigger the alphaherpesvirus to exit its latency stage?

A
  • sunburn
  • systemic infection
  • immune impairment
  • stress
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

how is the alphaherpesvirus prevented/treated?

A

prevention: avoid contact during active herpes recurrence
treatment: can only limit virus replication, will not eliminate infection

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

T/F: People unable to produce antibodies can still handle herpesvirus infections

A

true

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Betaherpesvirus key characteristics:

A

A) Restricted host range

B) Long reproductive cycle

C) Slow progression in cell culture

D) Enlargement of infected cells (cytomeglia)

E) Latent infection in a variety of tissues

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Gammaherpesvirus key characteristics:

A

A) Restricted host range

B) targets T & B lymphocytes

C) lytic infection

D) latency in lymphoid tissue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

the Epstein-Barr virus (EBV) is a member of which family?

A

Gammaherpesvirus

17
Q

Cytomegalovirus (CMV) is a member of what viral family?

A

Betaherpesvirus

18
Q

The Epstein-Barr virus is associated with what diseases?

A

1) EBV associated carcinoma
2) Burkett’s lymphoma
3) hodgkin’s lymphoma

19
Q

CMV (cytomegalovirus) will persist in _______ cells and in _____

A

hematopoietic progenitor cells

also in macrophages

20
Q

the CMV virus is controlled by a _______________

A

healthy, active immune system

21
Q

EBV (epstein-barr) will persist in ________ cells

A

persists in the genome of memory B cells

22
Q

____________ ensure B cell proliferation and the genome replication of the epstein-barr virus (EBV)

A

virus proteins

23
Q

T/F: beta and gamma herpes virus infections are usually self limiting in healthy individuals

A

true

24
Q

Antiviral therapy is recommended for which group infected with CMV or EBV?

A

immune compromised individuals

25
Q

T/F: there are no known vaccines for CMV or EBV

A

true

26
Q

Human Papillomavirus: family, genome and virion:

A
  • Papillomaviridae
  • circular dsDNA
  • non-enveloped
27
Q

HPV can gain access to the host through _______

A

abrasions of the skin

28
Q

HPV establishes infection in the _____ layer of the skin

A

basal

29
Q

what is required for the genome replication of HPV?

A

cell polymerase

30
Q

in what type of cells is the Human Pappiloma virus produced?

A

differentiating cells

31
Q

HPV is ________, meaning the virus is released only with the death of a cell

A

non-lytic

32
Q

by what routes is HPV spread?

A
  • direct skin-to-skin contact

- fomites

33
Q

Normal skin is a strong barrier to HPV, but the ___________ are more succeptable

A

mucous membranes

34
Q

T/F: the HPV virus is fragile and will not tolerate an environment outside the host

A

false- its hardy to environmental stresses

35
Q

what illnesses can HPV cause?

A

1) warts
2) respiratory papillomatosis
3) oncogenesis (cervical cancer)

36
Q

most treatments of HPV are ______, meaning they require the removal of host tissue

A

ablative

37
Q

Burkitt’s lymphoma is a cancer of ______ cells, while Hodgkin’s lymphoma is a cancer of ________

A

Burkitt’s lymphoma- B cells

Hodgkin’s- white blood cells (lymphocytes)

38
Q

what aspect of HPV’s lifecycle would lead it to cause cervical cancer?

A
  • HPV requires actively replicating cells to replicate
  • it produces enzymes (E6, E7, p53) that will keep the infected cells multiplying
  • uncontrolled mitosis leads to cancer
39
Q

what are the 3 methods that betaherpesviruses/gammaherpesviruses use to evade the host immune system?

A

1) intrinsic- block apoptosis
2) innate- prevent NK cells from working
3) adaptive- Decreased antigen presentation, block MHC

Immuno/micro final (16 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions