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Immuno/micro final > Middleton- childhood viral diseases > Flashcards

Middleton- childhood viral diseases Flashcards

1
Q

Measles is what type of virus?

A

paramyxovirus

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2
Q

the genome of the measles virus is ______

A

(-)ssRNA

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3
Q

when the measles virus replicates, _____ proteins cause syncytia formation

A

fusion proteins

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4
Q

how is the measles disease spread?

A

inhalation of aerosolized droplets

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5
Q

symptoms from the measles disease begin ____ days after infection

A

10-14

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6
Q

T/F: the Measles is the most deadly childhood rash/fever illness

A

true

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7
Q

what visible symptom is “characteristic” to measles?

A

the rash

-immune response to virus damages/kills epithelial cells

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8
Q

what are the symptoms of Measles?

A

2-3 day fever and cough

rash- the “Koplik spots”- bright red, small spots

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9
Q

T/F: measles in mildly contagious due to its need for a human host

A

FALSE- it is extremely contagious

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10
Q

what is the best way to prevent the measles?

A

vaccine

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11
Q

Respiratory Syncytial Virus is what type of virus?

A

paramyxovirus

just like measles

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12
Q

since the respiratory syncytial virus is a paramyxovirus, what is its genome type?

A

(-)ssRNA

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13
Q

unlike the Measles, Respiratory syncytial virus’ will infect _____ cells

A

ciliated cells (in the respiratory tract)

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14
Q

_____ protein creates syncytia

A

fusion

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15
Q

how does the respiratory syncytial virus exit the host cell?

A

buds from cellular surface

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16
Q

which virus is responsible for “the most important viral agent of serious pediatric respiratory tract infections”

A

Respiratory syncytial virus

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17
Q

the replication of the Respiratory syncytial virus is limited what?

A

the respiratory tract

18
Q

T/F: Respiratory syncytial virus can be spread from animals to humans

A

false- only human to human

19
Q

why does infection of the respiratory syncytial virus not yield lifelong immunity?

A

infants do not have a mature immune system

20
Q

what are the risk factors for contracting the Resp Syncytial virus

A
  • attending daycare

- school age siblings

21
Q

T/F: like the Measles, the best way to avoid the respiratory syncytial virus is to be vaccinated

A

False- no vaccine exists (yet)

22
Q

The Varicella Zoster virus is what kind of virus?

A

Alphaherpesvirus

alpha herpes virus

23
Q

The genome of the Varicella Zoster virus is ______, and is very large

A

dsDNA

24
Q

the Varicella Zoster virus replicates where?

A

within an ACTIVE cell

remember- dsDNA viruses need the cell’s polymerase

25
Q

if a cell thats infected with Varicella is resting, what stage is the virus in?

A

latent infection

26
Q

what disease does the Varicella Zoster Virus (VZV) cause?

A

chickenpox

27
Q

how long does the chickenpox virus (VZV) stay in its incubation period? low long do the symptoms last once it becomes active?

A

incubation- 10 to 21 days

recovery usually by 2 weeks after onset of symptoms

28
Q

if a latent infection of VZV becomes active, it causes _______

A

shingles

29
Q

the Poliovirus is what type of virus?

A

Picornavirus

30
Q

the genome of the Poliovirus is _______

A

(+)ssRNA

31
Q

what is different about the Virion of the poliovirus when compared to the other viruses discussed?

A

the poliovirus is non-enveloped

32
Q

particles of the Poliovirus create _____ in the cell

A

membrane pores

33
Q

the genome of the poliovirus (a +ssRNA) serves as ______

A

mRNA

34
Q

the poliovirus’ primary replication occurs where?

A

the “peyer’s patches” of the small intestine

35
Q

the poliovirus can replicate in the grey matter of the CNS. what can this cause?

A

limb paralysis

respiratory paralysis

36
Q

T/F: there are 2 different types of Poliovirus vaccines

A

true

salk- killed
sabin- live attenuated

37
Q

the Rotavirus is what type of virus?

A

Reoviridae

38
Q

Like the Poliovirus, the virion of Rotavirus is ______

A

non-enveloped

39
Q

what is unique about the Rotavirus genome’s replication?

A

the genome is never exposed during replication

40
Q

Rotavirus (the disease) causes what symptoms

A

Vomiting, fever, Diarrhea

41
Q

T/F: unlike Poliovirus, there are no known vaccines for Rotavirus

A

False: there are 2 different types

Immuno/micro final (16 decks)

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