Middleton- childhood viral diseases

Question 1

Measles is what type of virus?

Answer 1

paramyxovirus

Question 2

the genome of the measles virus is ______

Answer 2

(-)ssRNA

Question 3

when the measles virus replicates, _____ proteins cause syncytia formation

Answer 3

fusion proteins

Question 4

how is the measles disease spread?

Answer 4

inhalation of aerosolized droplets

Question 5

symptoms from the measles disease begin ____ days after infection

Answer 5

10-14

Question 6

T/F: the Measles is the most deadly childhood rash/fever illness

Answer 6

true

Question 7

what visible symptom is “characteristic” to measles?

Answer 7

the rash

-immune response to virus damages/kills epithelial cells

Question 8

what are the symptoms of Measles?

Answer 8

2-3 day fever and cough

rash- the “Koplik spots”- bright red, small spots

Question 9

T/F: measles in mildly contagious due to its need for a human host

Answer 9

FALSE- it is extremely contagious

Question 10

what is the best way to prevent the measles?

Answer 10

vaccine

Question 11

Respiratory Syncytial Virus is what type of virus?

Answer 11

paramyxovirus

just like measles

Question 12

since the respiratory syncytial virus is a paramyxovirus, what is its genome type?

Answer 12

(-)ssRNA

Question 13

unlike the Measles, Respiratory syncytial virus’ will infect _____ cells

Answer 13

ciliated cells (in the respiratory tract)

Question 14

_____ protein creates syncytia

Answer 14

fusion

Question 15

how does the respiratory syncytial virus exit the host cell?

Answer 15

buds from cellular surface

Question 16

which virus is responsible for “the most important viral agent of serious pediatric respiratory tract infections”

Answer 16

Respiratory syncytial virus

Question 17

the replication of the Respiratory syncytial virus is limited what?

Answer 17

the respiratory tract

Question 18

T/F: Respiratory syncytial virus can be spread from animals to humans

Answer 18

false- only human to human

Question 19

why does infection of the respiratory syncytial virus not yield lifelong immunity?

Answer 19

infants do not have a mature immune system

Question 20

what are the risk factors for contracting the Resp Syncytial virus

Answer 20

• attending daycare

- school age siblings

Question 21

T/F: like the Measles, the best way to avoid the respiratory syncytial virus is to be vaccinated

Answer 21

False- no vaccine exists (yet)

Question 22

The Varicella Zoster virus is what kind of virus?

Answer 22

Alphaherpesvirus

alpha herpes virus

Question 23

The genome of the Varicella Zoster virus is ______, and is very large

Answer 23

dsDNA

Question 24

the Varicella Zoster virus replicates where?

Answer 24

within an ACTIVE cell

remember- dsDNA viruses need the cell’s polymerase

Question 25

if a cell thats infected with Varicella is resting, what stage is the virus in?

Answer 25

latent infection

Question 26

what disease does the Varicella Zoster Virus (VZV) cause?

Answer 26

chickenpox

Question 27

how long does the chickenpox virus (VZV) stay in its incubation period? low long do the symptoms last once it becomes active?

Answer 27

incubation- 10 to 21 days recovery usually by 2 weeks after onset of symptoms

Question 28

if a latent infection of VZV becomes active, it causes _______

Answer 28

shingles

Question 29

the Poliovirus is what type of virus?

Answer 29

Picornavirus

Question 30

the genome of the Poliovirus is _______

Answer 30

(+)ssRNA

Question 31

what is different about the Virion of the poliovirus when compared to the other viruses discussed?

Answer 31

the poliovirus is non-enveloped

Question 32

particles of the Poliovirus create _____ in the cell

Answer 32

membrane pores

Question 33

the genome of the poliovirus (a +ssRNA) serves as ______

Answer 33

mRNA

Question 34

the poliovirus' primary replication occurs where?

Answer 34

the "peyer's patches" of the small intestine

Question 35

the poliovirus can replicate in the grey matter of the CNS. what can this cause?

Answer 35

limb paralysis respiratory paralysis

Question 36

T/F: there are 2 different types of Poliovirus vaccines

Answer 36

true salk- killed sabin- live attenuated

Question 37

the Rotavirus is what type of virus?

Answer 37

Reoviridae

Question 38

Like the Poliovirus, the virion of Rotavirus is ______

Answer 38

non-enveloped

Question 39

what is unique about the Rotavirus genome's replication?

Answer 39

the genome is never exposed during replication

Question 40

Rotavirus (the disease) causes what symptoms

Answer 40

Vomiting, fever, Diarrhea

Question 41

T/F: unlike Poliovirus, there are no known vaccines for Rotavirus

Answer 41

False: there are 2 different types