Microbiology 22: Opportunistic Viral Infections

Question 1

Which 2 organisms can cause Infective mononucleosis ?

Answer 1

CMV

EBV

Question 2

Which genetic mutation gives a predisposition to invasive Herpes simplex encephalitis ?

Answer 2

UNC93B

Question 3

What type of virus is HIV ?

Answer 3

Lentivirus

Question 4

Which cells does HIV target ?

Answer 4

CD4+ T cells

Question 5

Which Virus causes Kaposi Sarcoma ?

Answer 5

HHV8

Question 6

Which virus causes Burkitss lymphoma in HIV patients ?

Answer 6

EBV

Question 7

Which infections are people receiving anti -TNF therapy particularly predisposed to ?

Answer 7

Intracellular infections- TB

Question 8

Can BMT patients receive VZV vaccination ?

Answer 8

No because it is a live virus and they are immunocompromised.

Question 9

What is the difference in Immunocompromise of solid organ and bone marrow transplant patients ?

Answer 9

BMT patients are the most immunocompromised just before receiving the transplant because their own bone marrow is wiped out. After receiving the transplant a new immune system has to be established from the donors bone marrow.

Solid organ patients are less immunocompromised but then have to suppress their immune system for the rest of their lives.

Question 10

List different herpes viruses ?

Answer 10

HSV 1 and 2
VZV
CMV
EBV
HHV8
HHV6

Question 11

Where does VZV lay dormant ?

Answer 11

Dorsal root ganglia

Question 12

In which cells does CMV lay dormant ?

Answer 12

Monocytes

Question 13

In which cells does EBV lay dormant ?

Answer 13

B lymphocytes

Question 14

What is the main treatment for HSV infection ?

Answer 14

Acyclovir

Question 15

What are 2 treatment/prophylaxis of VZV options for immunocompromised or pregnant women ?

Answer 15

Prophylactic aciclovir

Post-exposure prophylaxis with VZig

Question 16

Which virus is associated with Progressive leukoencephalopathy ?

Answer 16

JC virus

Question 17

Which virus causes mouth ulcers in post transplant patients ?

Answer 17

HSV

Question 18

Which viruses causes a patient to be very unwell and appear septic with high fevers post bone marrow transplant ?

Answer 18

Adenovirus

Question 19

What is the typical serology of a patient with chronic hepatitis B infection ?

Answer 19

HBs Ag +ve
IgG HBc antibodies +ve
IgM HBc antibodies -ve
HBs antibodies -ve

Question 20

List 2 things that are caused by EBV in HIV patients ?

Answer 20

oral hairy leukoplakia

lymphomas: Burkitt’s lymphoma, Hodgkin’s

Question 21

Which disease is caused by EBV in patients post transplant ?

Answer 21

post-transplant lymphoproliferative disorder (PTLD)

Question 22

Which virus causes graft rejection ?

Answer 22

HHV6