Histopathology 21: Respiratory Pathology Flashcards
What does pulmonary oedema look like on histology ?
Intra-alveolar fluid
What is the name of the neonatal disease in which preterm babies have insufficient surfactant production ?
Hyaline membrane disease of the newborn
“On post-mortem examination of the lungs they are heavier than normal, expanded and firm. They are plumb coloured and airless”
Which disease does this describe ?
Acute lung injuries: ARDS or hyaline membrane disease of the newborn
List 4 acute changes to the airways in asthma ?
Bronchospasm
Oedema
Hyperaemia
Inflammation
List 4 chronic changes to the airways in asthma ?
Muscular hypertrophy
Airway narrowing
Goblet cell hyperplasia
Scarring
What are the histological findings of asthma ?
Eosinophils and mast cells Hypertrophic goblet cells Dilated vessels Thick muscular layer Charcot-Leyden Crystals
What are the histological findings of Chronic bronchitis?
Dilated airways
Mucous gland hyperplasia
Goblet cell hyperplasia
Mild inflammation
What are the histological findings of emphysema ?
Centrilobular damage to alveolar tissue
Panacinar (if alpha 1 anti trypsin deficiency)
List 5 pathologies seen with cystic fibrosis ?
Lungs- Thick mucous with recurrent infections G.I tract- meconium ileus Pancreas - pancreatitis Liver - cirrhosis Male reproductive system - Infertility
List histological features of Bronchopneumonia ?
Patchy bronchial/peri bronchial distribution often the lower lobes
Acute inflammation surrounding airways and in alveoli
List histological features of lobar pneumonia ?
Widespread fibrinosuppurative consolidation
Which tumours tend to arise in the airways ?
Squamous cell carcinomas
Which tumours tend to arise in the peripheral alveolar spaces ?
Adenocarcinomas
Which tumours tend to arise in the lung pleura ?
Mesothelioma
Which tumours tend to arise centrally or peripherally ?
Small cell lung cancer