Microbiology 17: Neonatal and childhood infections

Question 1

List 4 infectious diseases screened for during pregnancy ?

Answer 1

Hep B
HIV
Rubella
Syphilis

Question 2

What is the most common cause of congenital deafness in the UK ?

Answer 2

CMV

Question 3

Which disease is transmitted by cat poo ?

Answer 3

Toxoplasmosis

Question 4

What are some of the signs of congenital toxoplasmosis infection ?

Answer 4

60% asymptomatic 
Choroidoretinitis 
Microcephaly
Seizures
Hepatosplenomegally 
Intracranial calcification
Low IQ + deafness (later)

Question 5

What is the classical triad of signs of congenital rubella infection ?

Answer 5

Cataracts
Congenital heart disease
Deafness

Question 6

What signs do you get with congenital HSV infection ?

Answer 6

Blistering rash
Meningoencephalitis
Disseminated infection

Question 7

What can Chlamydia trachomatis cause in the neonate ?

Answer 7

Neonatal conjunctivitis

Pneumonia

Question 8

Which 3 organisms most commonly cause early onset (<48h) sepsis in the neonate ?

Answer 8

GBS (group b streptococcus)
E.coli
Listeria monocytogenes

Question 9

Which organism most commonly causes late onset (48-72h) sepsis in the neonate ?

Answer 9

Coagulase negative staphylococci (e.g s.epidermidis, s.saprophyticus)

Question 10

Which antibiotics are often used to treat early onset sepsis in the neonate?

Answer 10

Benzylpenicillin (treats GBS) + gentamicin (treats e.coli)

Question 11

Which bacteria classically causes superinfection with chicken pox ?

Answer 11

Invasive Group A streptococcus

Question 12

Bullous myringitis (vesicles on the tympanic membrane) and otitis media are suggestive of which organism ?

Answer 12

Mycoplasma Pneumoniae

Extra pulmonary manifestation

Question 13

Which bacteria causes whooping cough ?

Answer 13

Bordatella Pertussis