Histopathology 11: Upper G.I pathology Flashcards
In which part of the stomach does H.Pylori tend to reside ?
Pyloric antrum and pyloric canal
List the 3 layers of tissue seen on histology of the antrum and body of the stomach ?
- Collomnar epithelium
- Lamina propria (with specialised acid secreting glands)
- Muscularis mucosa
What is the normal villous: Crypt ratio in the duodenum ?
villous: crypt 2:1
What do goblet cells in the stomach suggest ?
Metaplasia
Which risk factors are associated with squamous cell carcinoma of the oesophagus ?
- Smoking and alcohol
- More common in afro-carribeans
Which risk factors are associated with adenocarcinoma of the oesophagus ?
- Barret’s oesophagus
- GORD
- smoking
- obesity
Which cancer is more common in the distal 1/3 of the oesophagus ?
Adenocarcinoma
Which cancer is more common in the middle 1/3 of the oesophagus ?
Squamous cell carcinoma
List 3 causes of acute gastritis ?
- NSAIDS
- Alcohol
- H.Pylori
List 3 causes of chronic gastritis ?
- H.Pylori
- Alcohol
- Pernicious anaemia
What does the presence of lymphoid follicles (MALT) in the stomach suggest ?
- H.Pylori infection
- Increased risk of lymphoma
What is meant by intestinal metaplasia of the stomach ?
-Goblet cells present in the stomach
Absence of Ganglion cells in the myenteric plexus
Hirsprung’s disease
Which type of cancer is most common in the stomach ?
Adenocarcinoma
Which complication is associated with Ulcerative colitis ?
Toxic megacolon
