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Romesh Path Fellah > Histopathology 6: Gynaecological pathology > Flashcards

Histopathology 6: Gynaecological pathology Flashcards

1
Q

What is the most common site of ectopic pregnancy ?

A

Ampulla of the fallopian tube

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2
Q

List 2 high risk HPV serotypes for cervical cancer ?

A

HPV 16

HPV 18

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3
Q

Which cells are characteristic of HPV on histology and appear to have a halo around the nucleus

A

Koilocytes

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4
Q

Describe CIN 1, CIN2, CIN 3, carcinoma?

A

CIN 1: Mild dyskaryosis limited to 1/3 of epithelium
CIN 2: Moderate dyskaryosis limited to 2/3 of epithelium
CIN 3: Severe dyskaryosis affecting entire epithelium
Carcinoma: Evidence of invasion through the basement membrane

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5
Q

At what age do girls receive the HPV vaccine ?

A

12-13

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6
Q

List 3 causes of PID ?

A

Chlamydia
Gonorrhoea
TB

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7
Q

What happens to the position of the uterus in severe endometriosis ?

A

It becomes retroverted

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8
Q

What is meant by chocolate cyst of the ovary?

A

Endometrioma

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9
Q

List 2 complications of Fibroids around pregnancy ?

A

Red degeneration

Post-partum torsion

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10
Q

What is the most common type of endometrial cancer ?

A

Endometroid adenocarcinoma

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11
Q

Which mutation is most commonly associated with Serous adenocarcinoma of the endometrium ?

A

P53

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12
Q

Define FIGO stage 1 of endometrial cancer

A

Confined to the endometrium

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13
Q

Define FIGO stage 2 of endometrial cancer

A

Spread to the cervix

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14
Q

Define FIGO stage 3 of endometrial cancer

A

Spread to adnexa, vagina or local lymph nodes

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15
Q

Define FIGO stage 4 of endometrial cancer

A

Distal metastasis or other pelvic organ spread

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16
Q

Into which 3 categories are ovarian tumour often subdivided ?

A
  • Epithelial
  • Germ cell
  • Sex cord/ stromal
17
Q

Which bilateral ovarian tumour is likely if Signet ring cells are present ?

A

Kreukenberg tumour

18
Q

List 4 epithelial cell Ovarian tumours ?

A

Serous cystadenoma
Mucinous cystadenoma
Endometroid
Clear cell

19
Q

Which ovarian tumour has Psamomma bodies ?

A

Serous cystadenocarcinoma

20
Q

Which ovarian tumour is associated with pseudomyxoma peritonei ?

A

Mucinous cystadenocarcinoma

21
Q

Which ovarian tumour has Walthard cell rests and “coffee bean” nuclei ?

A

Brenner tumour

22
Q

Which ovarian tumours contain ectodermal, endodermal and mesodermal cell lines ?

A

Teratoma (dermoid cyst)

23
Q

Which Ovarian tumour is histologicaly similar to a testicular seminoma and associated with Turner’s syndrome ?(Typically secrete hCG and LDH)

A

Dysgerminoma

24
Q

Which Ovarian germ cell tumour is associated with high levels of beta HCG ?

A

Choriocarcinoma

25
Q

Which germ cell ovarian tumours typically secrete AFP and show Schiller-Duval bodies on histology ?

A

Yolk sac tumours

26
Q

Which sex cord/ Stromal Ovarian tumour produces oestrogen leading to precocious puberty if in children or endometrial hyperplasia in adult?
(Histology shows Call-Exner bodies)

A

Granulosa (theca) cell tumour

27
Q

Which sex cord/ Stromal Ovarian tumour produces androgens leading to masculinizing effects?

Which syndrome is this tumour associated with ?

A

Sertoli-Leydig cell tumour

Peutz-Jegher syndrome

28
Q

Which ovarian tumour is associated with Peutz-Jegher syndrome

A

Sertoli-Leydig cell tumour

29
Q

Which ovarian tumour is associated with Meigs’ syndrome and tends to occur around the menopause ?

(histology shows bundles of spindle-shaped fibroblasts)

A

Fibroma

30
Q

List the triad of features seen in Meig’s syndrome ?

A

Fibromas
Ascites
Pleural effusions

31
Q

Describe FIGO stage 1 of Ovarian cancer ?

A

Limited to the ovaries

32
Q

Describe FIGO stage 2 of Ovarian cancer ?

A

Limited to the pelvis

33
Q

Describe FIGO stage 3 of Ovarian cancer ?

A

Limited to the abdomen

34
Q

Describe FIGO stage 4 of Ovarian cancer ?

A

Distant metastases outside of the abdominal cavity

35
Q

which vaginal cancer are children of women who were treated with diethyl stilbosterol for threatened abortion at increased risk of?

A

Clear cell carcinoma

Romesh Path Fellah (96 decks)

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