Microbio Chapter 25- Microbial diseases of the Digestive System Flashcards
What are microbial diseases that affect the oral cavity?
Dental caries
Periodental diseases
What bacteria causes dental caries?
Streptococcus mutans
What does S. mutans do to teeth?
Attaches to tooth via capsule and causes plaque to form and can lead to dental decay
What are 2 periodontal diseases?
- Gingivitis
- Periodontitis
What is gingivitis?
inflammation and bleeding of the gums
What bacterias cause gingivitis?
S. mutans
Bacteriodetes
Fusobacterium
What happens if gingivitis is not treated/maintained?
Can lead to Periodontitis
What is Periodontitis?
Pockets in gums form, gums recede and pus is produced. Teeth loosen and fall out.
What dental operation treats periodontitis?
A root canal
What bacteria causes chronic periodontitis?
A bacteriodoite called Porphyromonas gingivalis
-Producrs exotoxins and endotoxins contributing to the pus secretion
What is an infection (GI tract)?
Bacteria in food or water grow in the stomach during an incubation period
What is intoxication (GI Tract)?
Bacteria already growing in food gets eaten and toxins are ingested
What is gastroenteritis?
Bacteria causing inflammation of stomach and intestine
What treats infection/intoxication?
-oral rehydration therapy (ORT) e.g Electrolytes, soup
-Antibiotics
What are general symptoms of Gastroenteritis?
Fever,
nausea ,vomiting and diarrhoea or dysentry
Constipation
Shock
What are some bacterias affecting the digestive system?
Staphylococcus areus
Shigella dystenteriae
Salmonella enterica
Salmonella typhi
Vibrio cholerae
Escheria coli
Complyobacter jejuni
Helicobacter pylori
Clostridium difficile
What does S. aureus produce?
Superantigen (enterotoxin)
How is S. aureus spread?
Food like chicken, ham, creamy foods
How should food be stored to prevent S. aureus growth?
Hot food—> kept hot
Cold food—> kept cold
Food handler can contaminate food with bacteria
-Handwashing
What does S. dysenteriea produce?
Shiga toxin
How is S. dysenteriae spread?
Fecal oral route
Commonly spread in day cares
What does S. dysenteriae cause?
Shiga toxin in large intestine causes an abscess to form and leave scarring
-~20 bowel movements a day
-Dehydration
How is Shigellosis treated?
ORT
Fluoroquinolones
How is S. enteric (salmonellosis) spread?
Food source: Poultry, beef, raw eggs or veggies
Sometimes pets
How is S. typhi spread?
Human source only
-often life-long carriers
Where does S. typhi accumulate in the body?
Gallbladder
Who is Typhoid Mary?
Infamous typhoid carrier who allegedly gave rise to multiple outbreaks of typhoid fever.
How is Typhoid fever spread?
Fecal-oral route
Typhoid fever: Symptoms
Constipation, hemorrhaging, rose spots, rash and a VERY HIGH FEVER
How is Typhoid fever treated?
Cephalosporin
What does V. cholerae produce?
Vibriotoxin
What does V. cholerae cause?
Cholera
-Rice-water stools
-20L of lost fluid
-Shock, death
What country experienced a V. cholerae outbreak in 2010?
Haiti
How is V. cholerae treated?
ORT (w/ clean water)
Tetracycline
What are the 5 types of E. coli?
- ETEC
- EAEC
- EPEC
- EIEC
- EHEC
What is ETEC?
Entero Toxigenic E. coli
What is ETEC responsible for?
~60% of Traveller’s diarrhoea cases
What is EAEC?
entero Aggretative E. coli
What is EAEC responsible for?
~35-40% of traveller’s diarrhoea cases
What is EPEC?
Entero Pathogenic E. coli
What is EPEC responsible for?
Chronic diarrhoea in newborns
What is EIEC?
Entero invasive E. coli
What is EIEC responsible for?
Dysentry
What is EHEC?
Entero Hemorrhagic E. coli
What is EHEC responsible for?
Causes HUS
-Hemolytic Uremic Syndrome (kidney failure)
What does C. jejuni cause?
Gastroenteritis
What is a rare complication associated with C. jejuni?
Guillian-Barre syndrome
What is Guillian-Barre syndrome?
Causes paralysis
1/1000 chance
What does H. pylori cause?
Stomach ulcers
What structure does H.pylori bacteria have?
Flagella
What does H. pylori produce?
Exotoxin and enzyme
What does the exotoxin that H. pylori produces do?
Decreases stomach acid
What enzyme does H. pylori produce?
Urease
What does Urease do?
Degrades urea releasing ammonia, making environment less acidic
!!!MORE ALKALINE
How does H. pylori evade immune system cells?
Destroys phagocytes
How is H.pylori diagnosed?
Urea breath test
.What is a urea breath test?
Urea is swallowed and the amount of radioactive CO2 exhaled is measured
What is a symptom of H. pylori?
Extreme belching
How is H. pylori treated?
Metronidazole
What does C. diff cause?
Colitis
What does C. diff produce?
A-B exotoxin and exoenzymes
What structure does C. diff have?
Endospores
Where is C. diff commonly spread?
Nosocomial and day cares
How is C. diff treated?
Antibiotics
-Stop use and a new regimen is started
What are viral diseases affecting the digestive system?
Mumps
Hepatitis
Is Mumps preventable?
Yes, MMR vaccine (mumps, measles, rubella)
How long does Mumps incubate for?
After entry it incubates for 16-18 days and lodges
Symptoms of mumps?
Fever
Difficulty swallowing and talking —> Viral anorexia
Headache
Viremia
meningitis
Deafness
In males, mumps viremia causes what?
Orchitis
(Inflammation of testis)
In females, mumps viremia causes what?
Pelvic inflammation, ovaries affected
What are the different types of Hepatitis?
Hep A
Hep B
Hep C (Non A-B)
Hep D
Hep E
F, G, H
What is the infectious form of Hepatitis?
Hep A
How is Hep A transmitted?
Fecal-oral route
Is Hep A chronic?
No chronic form
Is Hep A preventable?
YES there is a vaccine that uses the inactivated form of the virus
What Hepatitis is the serum form (blood)?
Hep B
How is Hep B transmitted?
Blood, Injection drug use, semen
Is Hep B preventable?
YES there is a vaccine that uses recombinant technology using the capsid and genetically engineered yeast
What are the infectious particles of Hep B called?
Dane particles
-Which are complete virions
Is Hep B chronic?
85% recover from acute
15% chronic, dane particle stays= Cancer
How is Hep B treated?
Lamivudine ®
How is Hep C (Non A-B) transmitted?
Blood, injection drug users, semen
Is Hep C preventable?
No there isn’t a vaccine
Is Hep C chronic?
85% are chronic
15% liver disease
How is Hep C treated?
Ribavirin + Interferon®
How is Hep D transmitted?
Hep D only occurs in people infected with Hep B. Hep D is spread from person to person via blood.
Is Hep D preventable?
Yes, the vaccine for Hep B
(Recombinant: yeast+capsid) to prevent Hep D infection
Why is Hep D defective?
It is missing a capsid
Is Hep D chronic?
-Patient with acute Hep B will have acute Hep D
Patient with chronic Hep B will have chronic Hep D
How is Hep E transmitted?
Fecal-oral route
What hepatitis does Hep E resemble?
Hep A
Is Hep E chronic?
No but it is responsible for a 20% mortality rate in pregnant women
Is Hep E preventable?
Yes, HAV vaccine