Methylprednisolone (Solu-Medrol)

Question 1

Classification

Answer 1

Corticosteroid

Question 2

Mechanism of Action

Answer 2

• Reduces inflammation by multiple mechanisms

Question 3

Indications

Answer 3

• Severe anaphylaxis
• Asthma
• COPD

Question 4

Contraindications

Answer 4

• Cushing’s syndrome
• Fungal infections
• Measles
• Varicella
• Known sensitivity, including sulfites
• No others in emergency setting

Question 5

Adverse Effects

Answer 5

• Depression, euphoria
• Headache, restlessness, nausea, vomiting, diarrhea
• HTN
• Bradycardia
• Swelling, fluid retention

Question 6

Administration

Answer 6

• Asthma, COPD, & Anaphylactic Shock
  
  • ​Adult: 125 mg IV/IO/IM
  • Peds: 1 mg/kg (up to 60 mg) IV/IO per day in two divided doses