Mental health Flashcards

Condition and Presentation

1
Q

Anorexia nervosa

A

serious mental health disorder characterized by self-imposed starvation and a relentless pursuit of extreme thinness.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Subtypes of anorexia

A

*. Restrictive Subtype: Characterized by minimal food intake and excessive exercise.

  • Bulimic Subtype: Involves episodic binge eating followed by behaviors like laxative use or induced vomiting.
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

ICD-11 Criteria:

A
  • Significantly Low Body Weight
  • Fear of Gaining Weight
  • Distorted Body Image
  • Restrictive Eating
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

DMS-5 criteria anorexia

A
  • Restriction of Energy Intake
  • Intense Fear of Gaining Weight
  • Body Image Disturbance
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Anorexia nervosa

A
  • more common in females
  • more common in dev countries
  • co-occurs with other psychiatric disorders, such as depression and anxiety
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Signs and symptoms of anorexia

A

Hypotension
Bradycardia
Enlarged salivary glands
Lanugo hair (fine hair covering the skin)
Amenorrhoea

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

BMI- AN vs Bulemia

A
  • bulemia may have normal BMI
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

AN blood investigations q

A
  • Deranged electrolytes - typically low calcium, magnesium, phosphate and potassium
  • Low sex hormone levels (FSH, LH, oestrogen and testosterone)
  • Leukopenia
  • Raised growth hormone and cortisol levels (stress hormones)
  • Hypercholesterolaemia
  • Metabolic alkalosis, either due to vomiting or use of diuretics
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Managment of AN

A
  • CBT
  • MANTRA
  • SSRI
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

When to admit patients for ano

A

USS test (sit-up, squat, and stand). Admission is also indicated if proximal muscle weakness suggests weak respiratory muscles.

If patients are very unwell the MARSIPAN checklist should be used to guide management.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Refeeding syndrome

A

A potentially fatal disorder that occurs when nutritional intake is resumed too rapidly after a period of low caloric intake

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Symptoms of refeed syndrome

A

oedema, confusion and tachycardia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Electrolytes in refeed syndrome

A

Rapidly increasing insulin levels lead to shifts of potassium, magnesium and phosphate from extracellular to intracellular spaces‚ these need to be replenished

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Managment of refeed syndrome

A
  • high-dose vitamins (eg. Pabrinex) before feeding commences
  • Monitoring with daily bloods and replenishing electrolytes early
  • Building caloric intake gradually with the help of a dietitian‚ NICE recommends that refeeding is started at no more than 50% of calorie requirement
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

cardiac symptoms assoicated with cardiac arrhythmias

A

Bradycardia and prolonged QTc are often seen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Negative prognostic factors for ano

A
  • Presentation after the age of 20 years‚ difficult to reverse fixed beliefs
  • BMI <16 kg/m2
  • Marked anxiety when eating in front of others, which indicates issues with socialisation
  • Binging/vomiting responds less well to CBT than starvation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Cautions of SSRI

A
  • Avoid in mania
  • Should be used with caution in children and adolescents
  • Sertraline is best for patients with ischaemic heart disease
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

SSRI side effects

A
  • GI upset
  • Anxiety and agitation
  • QT interval prolongation (especially associated with citalopram)
  • Sexual dysfunction
  • Hyponatraemia
  • Gastric Ulcer
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Seretonin syndrome triad

A
  • mental status changes
  • autonomic hyperactivity
  • neuromuscular abnormalities
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Managment of Seretonin syndrome

A

discontinuation of the offending drug and supportive care.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

SNRIs side effects

A
  • Nausea
  • Insomnia
  • Increased heart rate
  • Agitation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

NaSSAs side effects

A

Sedation
Increased appetite
Weight gain
Constipation/diarrhoea

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

TCA cautions

A
  • Contraindicated in those with previous heart disease
  • Can exacerbate schizophrenia
  • May exacerbate long QT syndrome
  • Use with caution in pregnancy and breastfeeding
  • May alter blood sugar in T1 and T2 diabetes mellitus
  • May precipitate urinary retention, so avoid in men with enlarged prostates
  • Uses the Cytochrome P450 metabolic pathway, so avoid in those on other CP450 medications or those with liver damage
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

TCA side effects

A

Urinary retention
Drowsiness
Blurred vision
Constipation
Dry mouth

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

TCA toxicity signs

A

drowsiness, confusion, arrhythmias, seizures, vomiting, headache, flushing, and dilated pupils

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

Investigations of TCA overdose

A

blood tests (FBC, UE, CRP, LFTs), Venous Blood Gas, and an ECG to check for QT interval prolongation.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

Managment of TCA overdose

A
  • Supportive care based on patient symptoms
  • NAC or charcoal in 2-4 hours
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

Cautions of MAO inhibitors

A

Cerebrovascular disease
Manic phase of bipolar disorder
Phaeochromocytoma
Severe cardiovascular disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

Side effects of MOA inhib

A

Hypertensive reactions (‘cheese reaction’) with tyramine-containing foods (so patients need to avoid pickled herring, Bovril, Oxo, Marmite, cheese, salami).
Should also avoid broad bean pods as these contain dopa.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

class A personality disorders

A
  • PARANOID PERSONALITY DISORDER
  • SCHIZOID PERSONALITY DISORDER
  • SCHIZOTYPAL PERSONALITY DISORDER
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

PARANOID PERSONALITY DISORDER

A

Characterised by a pervasive and enduring pattern of irrational suspicion and mistrust of others
Demonstrates hypersensitivity to criticism and potential slights
Exhibits reluctance to confide in others due to fear of information being used maliciously against them
Often preoccupied with unfounded beliefs about perceived conspiracies against themselve

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

Schizoid personality disorder

A

Characterised by an enduring pattern of detachment from social relationships and a restricted range of emotional expression
Displays a pervasive lack of interest in or desire for interpersonal relationships, often preferring solitary activities
Shows an emotional coldness, detachment, or flattened affectivity
Often has few, if any, close relationships outside of immediate family

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
33
Q

Schizotypal personality disorder

A

Characterised by a chronic pattern of impaired social interactions, distorted cognitions and perceptions, and eccentric behaviours
Demonstrates inappropriate or constricted affect, and peculiar, eccentric or bizarre behaviour
Displays odd thinking and speech, such as magical thinking, peculiar ideas, paranoid ideation, and belief in the influence of external forces
Shares certain cognitive or perceptual distortions with schizophrenia, but maintains a more intact grasp on reality

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
34
Q

Class B personality disorders

A

ANTISOCIAL PERSONALITY DISORDER
BORDERLINE PERSONALITY DISORDER
HISTRIONIC PERSONALITY DISORDER
NARCISSISTIC PERSONALITY DISORDER

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
35
Q

ANTISOCIAL PERSONALITY DISORDER

A

Defined by a pervasive pattern of disregard for and violation of the rights of others.
Individuals with this disorder exhibit a lack of empathy and frequently engage in manipulative, impulsive actions.
Manifestations include aggressive, unremorseful behaviour, and consistent irresponsibility, which often results in a failure to obey laws and social norms.
Children diagnosed with conduct disorder are at increased risk of developing this as they grow older. Prevention can be through parenting programmes, as well as trialling group-based CBT.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
36
Q

BPD

A

Characterised by a recurring pattern of abrupt mood swings, unstable personal relationships, and self-image instability.
The propensity towards self-harm is commonly observed in these patients.
Relationships often fluctuate between extremes of idealisation and devaluation, a process known as “splitting”.
There is often an inability to control temper and manage affective responses appropriately.
Also known as emotionally unstable personality disorder (EUPD) there may be a history of previous trauma, including sexual abuse.
Management is with dialectical behavioural therapy (DBT).

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
37
Q

Histronic personality disorder

A

Predominantly characterised by attention-seeking behaviours and excessive displays of emotion.
Individuals may display inappropriate sexual behaviours.
Their emotional expressions tend to be shallow, dramatic, and often perceived as exaggerated.
They often perceive relationships as being more intimate than they truly are, reflecting a distorted perception of interpersonal boundaries.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
38
Q

Narcissistic personality disorder

A

Characterised by a persistent pattern of grandiosity, a strong need for the admiration of others, and a marked lack of empathy.
Individuals with this disorder often display a sense of entitlement and will exploit others to fulfil their own desires.
Tendency to be arrogant and preoccupied with personal fantasies and desires, often at the cost of disregarding others’ feelings and needs.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
39
Q

Class C personality disorder

A

AVOIDANT PERSONALITY DISORDER
DEPENDENT PERSONALITY DISORDER
OBSESSIVE-COMPULSIVE PERSONALITY DISORDER

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
40
Q

OCD

A

Characterised by an excessive preoccupation with orderliness, perfectionism, and control, often at the expense of flexibility, openness, and efficiency
Contrary to obsessive-compulsive disorder (OCD), obsessive-compulsive personality disorder (OCPD) is not associated with recurrent, intrusive thoughts or rituals
Indications may include strict adherence to routines, perfectionism to the point of dysfunction, and a persistent reluctance to delegate tasks to others
Symptoms are generally ego-syntonic, meaning the patient perceives them as rational and desirable, thereby differentiating OCPD from OCD, where symptoms are typically ego-dystonic and distressing to the individual.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
41
Q

Dependant personality disorder

A

Characterised by a pervasive and excessive need to be taken care of, leading to submissive and clinging behaviour
Individuals often lack self-confidence and initiative, relying excessively on others for decision-making
Patients may urgently seek new relationships as a source of care and support when existing ones end

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
42
Q

Avoidant personality disorder

A

Characterised by intense feelings of social inadequacy, fear of rejection, and hypersensitivity to criticism
* Patients often self-impose isolation to avoid potential criticism, despite a strong desire for social acceptance and interaction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
43
Q

Bullimia nervosa

A

binge-eating episodes followed by compensatory behaviors, such as self-induced vomiting, laxative abuse, diuretics, fasting, or excessive exercise

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
44
Q

epidemiology of Bulimia nervosa

A

Affects adolescents and young adults, with onset in late adolescence or early adulthood.
Prevalence: Lifetime 1-2% in women, less than 0.5% in men.
Female to male ratio: Approximately 10:1.
Relatively stable prevalence over the last few decades.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
45
Q

Psychological symptoms of bulimia

A
  • Binge Eating: Loss of control, consuming large amounts of high-caloric food urgently.
  • Purging: Induced vomiting, laxative or diuretic misuse, and excessive exercise.
  • Body Image Distortion: Distorted perception despite maintaining normal or slightly above average weight.
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
46
Q

Physical symptoms of bulimia

A

Dental Erosion: Resulting from recurrent self-induced vomiting.
Parotid Gland Swelling: Resulting from recurrent self-induced vomiting.
Russell’s Sign: Scarring on the back of the hand or knuckles from repeated self-induced vomiting.
Amenorrhea: Present in 50% despite normal weight.
Excessive Vomiting Complications: Boerhaave syndrome or Mallory-Weiss tear.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
47
Q

Wernicke’s encephalopath

A

Acute neurological syndrome resulting from a deficiency in thiamine (vitamin B1).

Related to chronic alcohol abuse

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
48
Q

Wernicke’s encephalopath triad

A
  • mental status changes (confusion)
  • ataxia,
  • ophthalmoplegia/nystagmus.
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
49
Q

Korsakoff’s syndrome symptoms

A
  • Profound anterograde amnesia
  • Limited retrograde amnesia
  • Confabulation (patients fabricate memories to mask their memory deficit)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
50
Q

Investigations of Wernicke’s encephalopathy

A
  • Thiamine level testing: Low levels are indicative of deficiency.
  • FBC
  • Urea and Electrolytes
  • Liver Profile
  • Clotting
  • Bone Profile
  • Magnesium
  • MRI can show typical changes in specific regions of the brain, as well as mamillary body atrophy in Korsakoff’s syndrome.
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
51
Q

Management of Wernicke’s encephalopath

A
  • find underlying issue
  • Thiamine supplementation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
52
Q

Management of Korsakoff’s syndrome

A
  • thiamine suplements
  • rehab (+alcohol support)
  • managment of patient’s environment
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
53
Q

Transient global amnesia (TGA)

A

sudden, transient neurological condition primarily characterized by acute disruption of both short-term and long-term memory.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
54
Q

epidemiology of TGA

A

middle-aged and elderly individuals

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
55
Q

Features of TGA

A
  • Sudden onset of memory loss
  • retrograde amnesia
  • anterograde amnesia
  • confusion/ dejavu
    *preserved personality
    *motor skills normal
  • Spontaneous resolution of symptoms, typically within 24 hours
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
56
Q

TGA investigations

A
  • Brain CT or MRI
  • EEG
  • Neuropsychological tests
  • Blood tests: To exclude metabolic causes such as hypoglycemia or electrolyte imbalance
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
57
Q

Managment of TGA

A
  • Reassurance:
  • Supervision
  • Follow-up: A neurological review is advised, especially if episodes are recurrent.
  • There are no specific pharmacological treatments for TGA.
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
58
Q

TGA and DVLA

A

No need to inform

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
59
Q

criteria to be detained mental health act

A
  • They must have a mental disorder
  • There must be a risk to their health/safety or the safety of others
  • There must be a treatment (however this can include nursing care, not just drugs)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
60
Q

MHA Section 2

A
  • Admission for mental health assessment and treatment for up to 28 days,
  • non-renewable.
  • The application for admission is initiated by an Approved Mental Health Professional (AMHP) or the patient’s nearest relative.
  • This section necessitates the recommendation of two doctors, one of whom must be ‘approved’ under Section 12(2) of the MHA
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
61
Q

MHA section 3

A
  • Permits admission for treatment lasting up to 6 months, with the provision for renewal.
  • Mandates the involvement of an AMHP and two doctors, both of whom should have examined the patient within the last 24 hours.
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
62
Q

MHA section 4

A
  • Designed for emergencies when applying Section 2 would cause an unnecessary delay.
  • Requires the recommendation of a single doctor and the involvement of either an AMHP or the nearest relative.
  • The patient can be detained for a maximum of 72 hours, typically followed by a transition to Section 2.
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
63
Q

MHA Section 5(2)

A

Holding power which enables a doctor to legally detain a voluntary patient in the hospital for a period of 72 hours.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
64
Q

MHA section 5(4)

A

Section 5(4) is comparable to a Section 5(2) but is enacted by registered nurses and has a duration of 6 hours.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
65
Q

Section 17a

A

Allows for a Supervised Community Treatment (also known as a Community Treatment Order).

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
66
Q

Section 135

A

Court order enabling the police to enter a property to escort a person to a Place of Safety (either the police station or, more commonly, an Accident and Emergency Department (A&E)).

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
67
Q

Section 136

A

Provides police officers the authority to take an individual, who seems to be suffering from a mental disorder and is in a public place, to a Place of Safety.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
68
Q

Investigations for paracetamol overdose

A

Full Blood Count (FBC)
Urea and Electrolytes
Clotting Screen
Liver Function Tests
Venous Blood Gas - Severe metabolic acidosis
Paracetamol level

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
69
Q

Managment of paracetamol overdose

A

Charcoal
NAC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
70
Q

Classificiations of paracetamol overdose

A

Acute overdose - excessive amounts in less than 1 hour, usually in context of self-harm)
Staggered overdose - excessive amounts of paracetamol ingested over longer than 1 hour, usually in context of self harm)
Therapeutic excess - excessive paracetamol taken with intent to treat pain or fever and without self-harm intent, ingested at dose greater than licensed daily dose (more than 75mg/kg/24 hours).

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
71
Q

OCD managment

A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
72
Q

Postpartum psychosis

A

serious psychiatric disorder that typically develops within the first two weeks following childbirth

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
73
Q

Postpartum psychosis syptoms

A

Paranoia
Delusions
Capgras delusions - misidentification syndrome characterised by the belief by the patient that the close person is replaced by an imposter who looks physically the same
Hallucinations
Manic episodes
Depressive episodes
Confusion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
74
Q
A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
75
Q

Managment of postpartum psychosis

A
  • Antipsychotic medications - olanzapine and quetiapine are safe to take while breastfeeding
  • Mood stabilisers in some instances
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
76
Q

Schizophrenia

A

hronic or relapsing and remitting form of psychosis characterized by positive symptoms (such as hallucinations, delusions, thought disorders) and negative symptoms (including alogia, anhedonia, and avolition)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
77
Q

Criteria for Schizophrenia

A

ICD-11 Criteria: Symptoms present for at least 1 month, causing significant impairment.

DSM-5 Criteria: Symptoms persist for at least 6 months, encompassing at least one month of active-phase symptoms (must include one prominent ‘ABCD’ symptom).

78
Q

Subtypes of schizophrenia

A

Paranoid Schizophrenia: Characterized by delusions and hallucinations, often with a persecutory theme.

Catatonic Schizophrenia: Features motor disturbances and waxy flexibility.

Hebephrenic Schizophrenia: Marked by disorganized thinking, emotions, and behavior.

Residual Schizophrenia: Residual symptoms persist after a major episode.

Simple Schizophrenia: Characterized by a gradual decline in functioning without prominent positive symptoms.

79
Q
A
80
Q

Typical antipsychotic

A
  • first-generation’ antipsychotics
  • antagonists to D2 receptors but also on cholinergic, adrenergic and histaminergic receptors
81
Q

Extrapyramidal symptoms of typical antipsychotic 4

A
  • Acute Dystonia: Involuntary muscle contractions causing spasms.
  • Akathisia: Restlessness and an inability to sit still.
  • Parkinsonism: Tremors, rigidity, and bradykinesia (slowed movements).
  • Tardive Dyskinesia: Involuntary, repetitive movements, especially of the face.

Hyperprolactinemia

82
Q

Histamine H1 Receptor Blockade

A

Drowsiness and sleepiness

83
Q

Alpha-1 Adrenergic Receptor Blockade

A

Orthostatic hypotension

84
Q

Anticholinergic Effects of typical antipsychotic

A

Dry mouth.
Constipation.
Blurred vision.
Urinary retention.

85
Q

Atypical anti psychotic

A

D2, D3 and 5-HT2A antagonists, with less overspill into other receptors.

86
Q

Examples of atypical antipsychotics

A

risperidone, quetiapine, olanzapine, aripiprazole and clozapine

87
Q

EPS (Extrapyramidal Symptoms) atypical

A
  • lower risk of causing EPS compared to typicals.
    Lower risk of tardive dyskinesia.
88
Q

5-HT2A Receptor Blockade atypical

A

Atypicals have a reduced risk of causing EPS due to serotonin receptor blockade.

89
Q

Monitoring atypical antipsychotic

A
  • weight (weeks, then at 12 weeks, at 1 year, and then yearly.)
  • fasting blood glucose, HbA1c, blood lipids
  • Prolactin baseline
  • ECG
  • blood pressure (12 weeks and one year)
90
Q

Clozapine

A
  • atypical antipsychotic that is indicated if there is failure of treatment of 2 other antipsychotic medication
  • treatment- resistant schizophrenia
91
Q

Side effects of clozapine

A

agranulocytosis, neutropenia, reduced seizure threshold, myocarditis, slurred speech (due to hypersalivation), constipation

92
Q

Monitoring clozapine

A

FBC

Blood lipids and weight

Blood lipids and weight

93
Q

Neuroleptic malignant syndrome

A

potentially life-threatening, idiosyncratic reaction to antipsychotic medications, particularly those that block dopamine receptors.

94
Q

Clinical features of NMS

A
  • hyperthermia
  • altered mental state
  • autonomic dysregulation
  • rigidity
95
Q

NMS investigation

A

FBC - Monitoring for potential leukocytosis or signs of infection.
Creatine Kinase (CK) Levels: Markedly elevated CK levels are often observed due to muscle breakdown.
Renal and Liver Function Tests: monitoring organ function due to the potential systemic effects.

96
Q

Management of NMS

A
  • discontinue causative agent
  • supportive care ( aggressive cooling)
  • benzodiazepines
  • dantrolene
  • intensively monitoring
97
Q

ICD-11 criteria GAD

A

Excessive worry and apprehension.
Difficulty controlling worry.
Associated symptoms: Restlessness, muscle tension, fatigue.
Duration: At least 6 months.

98
Q

DSM-V Criteria: GAD

A

Excessive anxiety and worry about various domains.
Difficulty controlling worry.
Associated symptoms: Restlessness, muscle tension, fatigue, irritability.
Duration: At least 6 months.

99
Q

GAD epidemiology

A
  • common in females
  • associates with depression, substance abuse and personality disorder
  • onset 35-40 years is more likely indicative of depressive disorder or organic disease.
100
Q

Risk factors of GAD

A

lower socioeconomic status, unemployment, divorce, renting rather than owning a home, lack of educational qualifications, and urban living.

101
Q

Psychological symptoms GAD

A

Fears, worries, poor concentration, irritability, depersonalization, derealization, insomnia, night terrors

102
Q

Motor symptoms GAD

A

Restlessness, fidgeting, a feeling of being on edge

103
Q

GAD Neuromuscular

A

Tremor, tension headache, muscle ache, dizziness, tinnitus

104
Q

GI GAD symptoms

A

Dry mouth, dysphagia, nausea, indigestion, “butterflies” in the stomach, flatulence, frequent or loose bowel movements

105
Q

Cardiolovascular symptoms GAD

A

Chest discomfort, palpitations

106
Q

Genitourinary GAD symptoms

A

Urinary frequency, erectile dysfunction, amenorrhea

107
Q

Respiratory symptoms GAD

A

Dyspnea, tight/constricted chest

108
Q

Management

A

Psycho- education
Self help
CBT
SSRI
Propranolol

Patients under 30 should therefore have a follow-up appointment within 1 week to monitor progress.

109
Q

ICD-11 criteria panic disorder

A

Recurrent, unexpected panic attacks.
At least one attack followed by a month of persistent concern.
Avoidance behaviors related to attacks.

110
Q

DSM-V criteria panic tracks

A

Recurrent, unexpected panic attacks.
Persistent concern about future attacks.
Behavioral changes: Avoidance of situations associated with attacks.

111
Q

Epidemiology of panic disorder

A

Prevalence of 1-2% in the general population.
2-3 times more prevalent in females.
Bimodal incidence, peaking at ages 20 and 50.
Agoraphobia is concurrent in 30-50% of cases.
Increased risk of attempted suicide with comorbid depression, alcohol misuse, or substance misuse.

112
Q

Clinical feature of panic disorder

A

Difficulties in breathing.
Chest discomfort.
Palpitations.
Hyperventilation
Numbness
Shaking, sweating, dizziness.
Depersonalization/derealization.
May result in fear of situations where panic attacks occur or lead to agoraphobia.
Development of a conditioned fear-of-fear pattern.

113
Q

Management of panic disorder

A
  • CBT
  • fear of fear cycles
    *SSRI
  • Clomipramine
114
Q

increased risk of going on to complete suicide:

A
  • hx self harm or prev suicide attempt
  • mental health disorder (e.g depression, bipolar disorder)
  • male
  • drugs and alcohol use
  • planned attempt
  • poor social support
115
Q

Risk management suicide

A
  • mild risk - primary care as long as patient as established support network with GP follow ups
  • moderate severe risk A&E/admitted and reviewed by Psychiatry liaison team
116
Q

Delirium symptoms

A

Disorientation
Hallucinations - visual or auditory
Inattention
Memory problems
Change in mood or personality. Sundowning is agitation and confusion worsening in the late afternoon or evening.
Disturbed sleep

117
Q

Management of delirium

A
  • sleep hygiene
  • haloperidol or lorazepam. Olanzapine
118
Q

What is the concordance rate for schizophrenia in twin studies?

A

50%

This indicates a significant genetic component in the risk of developing schizophrenia.

119
Q

What psychological factors often precede psychosis?

A

Anger, depression, and ideas

These factors may lead to interventions such as CBT to reduce the risk of full psychosis.

120
Q

What social factors are linked to the onset of psychosis?

A

Social deprivation, urbanization, and stressful life events

These factors can contribute to increased stress, which is associated with psychotic disorders.

121
Q

What was the original name for schizophrenia?

A

Dementia

This reflects historical perspectives on the disorder before it was redefined as schizophrenia.

122
Q

Which gender is more frequently affected by schizophrenia?

A

Men

Schizophrenia typically arises before the age of 40 and is more prevalent in men.

123
Q

What neurotransmitter activity is thought to give rise to positive symptoms of schizophrenia?

A

Excessive dopamine activity

Positive symptoms include delusions and hallucinations.

124
Q

Where in the brain is dopamine important for executive function?

A

Mesocortical (Pre-frontal cortex)

This area is associated with negative symptoms such as apathy and anhedonia.

125
Q

What symptoms are associated with dopamine activity in the basal ganglia?

A

Increased voluntary motor activity

This explains the extrapyramidal side effects seen with antipsychotic medications.

126
Q

What is a hallucination?

A

A sensory experience that appears real but is created by the mind

Patients may hear voices or see things that are not present.

127
Q

Define delusion.

A

A false belief maintained with strong conviction despite contradictory evidence

Delusions are often culturally incongruent.

128
Q

What is thought disorder?

A

An impaired capacity to sustain coherent discourse

This can manifest in both written and spoken language.

129
Q

What is catatonia?

A

Abnormal movements experienced by some patients

This can include a range of behaviors from immobility to excessive movement.

130
Q

Fill in the blank: The most famous psychotic condition is _______.

A

Schizophrenia

Schizophrenia is widely studied and recognized in the field of psychiatry.

131
Q

What is waxy flexibility in patients?

A

A condition where a patient can be moved into a position and remains frozen there.

Waxy flexibility is often observed in catatonic states.

132
Q

Define catatonic stupor.

A

A state where a patient suddenly stops and remains immobile.

This is a key feature of catatonic disorders.

133
Q

What are passivity phenomena?

A

The belief that one’s thoughts or actions are no longer one’s own.

This includes thought insertion, thought broadcasting, and thought withdrawal.

134
Q

What is thought insertion?

A

The belief that someone else is putting a thought into one’s head.

This is one of the types of passivity phenomena.

135
Q

What is thought broadcasting?

A

The belief that everyone can read your thoughts.

This is another form of passivity phenomena.

136
Q

What is thought withdrawal?

A

The belief that thoughts are being taken out of one’s mind.

This completes the triad of passivity phenomena.

137
Q

What are negative symptoms in the context of schizophrenia?

A

Symptoms defined by their absence, such as lack of emotion or social withdrawal.

This can be remembered by the 5 A’s.

138
Q

List the 5 A’s associated with negative symptoms.

A
  • Affect blunted
  • Alogia
  • Asociality
  • Anhedonia
  • Avolition

These terms describe various aspects of diminished emotional expression and social engagement.

139
Q

What does affect blunted refer to?

A

Restricted emotion with poor emotional display.

This is one of the 5 A’s of negative symptoms.

140
Q

What is alogia?

A

Paucity of speech.

This is another aspect of negative symptoms.

141
Q

Define asociality.

A

Social isolation or lack of interest in social interactions.

This is also part of the negative symptoms.

142
Q

What is anhedonia?

A

Lack of pleasure or interest in activities.

This symptom is significant in various mental health disorders.

143
Q

What is avolition?

A

Lack of motivation to initiate and sustain activities.

This is the fifth A in the negative symptoms framework.

144
Q

What are the criteria for diagnosing schizophrenia?

A

At least 2 of the following experienced for 1 month:
* Delusions
* Hallucinations
* Disorganized speech
* Disorganized or catatonic behavior
* Negative symptoms

At least one of the first three must be present.

145
Q

What characterizes paranoid schizophrenia?

A

Prominent hallucinations and delusions with mostly normal intellectual functioning and emotion.

Patients often feel suspicious and persecuted.

146
Q

What is catatonic schizophrenia?

A

An uncommon type characterized by prominent psychomotor disturbances.

Symptoms may include rigidity, posturing, and abnormalities of voluntary movement.

147
Q

What are the types of schizophrenia?

A
  • Paranoid
  • Undifferentiated
  • Catatonic
  • Disorganized
  • Residual
  • Hebephrenic/Disorganized

Each type has distinct features and symptoms.

148
Q

What characterizes Paranoid schizophrenia?

A

Delusions of persecution and grandeur

Patients may believe they are being targeted or possess special powers.

149
Q

What are the symptoms of Undifferentiated schizophrenia?

A

Symptoms that don’t clearly fit one of the other types

This subtype lacks specific characteristics of other classifications.

150
Q

What phases are involved in Catatonic schizophrenia?

A

Excitement and stupor phases

Patients may alternate between extreme agitation and lack of movement.

151
Q

What defines Disorganized schizophrenia?

A

Bizarre behavior, delusions, and hallucinations

Symptoms can include incoherent speech and inappropriate emotional responses.

152
Q

What are the features of Hebephrenic/Disorganized schizophrenia?

A
  • Early onset
  • Unpredictable behavior and speech
  • Inappropriate affect and mood
  • Fleeting hallucinations and delusions

This type often presents with immature behaviors.

153
Q

What is Residual schizophrenia?

A

A long-term subtype where most symptoms have gone but negative symptoms remain

Patients may retain some cognitive or emotional deficits.

154
Q

What is the primary management for schizophrenia?

A

Oral antipsychotics in a staged approach

Treatment is tailored based on the patient’s response and needs.

155
Q

What is considered the 1st line treatment for schizophrenia?

A

Oral atypical antipsychotics (quetiapine, alanzapine, risperidone)

Atypical antipsychotics are preferred due to a better side effect profile.

156
Q

What are examples of 2nd line treatment options for schizophrenia?

A

Oral typical antipsychotics (haloperidol, chlorpromazine)

These medications are often used if atypical antipsychotics are ineffective.

157
Q

What is the 3rd line treatment for schizophrenia?

A

Clozapine, used for psychosis refractory to other treatments

Clozapine requires careful monitoring due to potential side effects.

158
Q

What should be regularly monitored when prescribing antipsychotics?

A
  • Weight
  • Lipids
  • Glucose
  • ECGs

Monitoring helps manage the risk of metabolic syndrome and other side effects.

159
Q

What is the minimum dose strategy for prescribing antipsychotics?

A

Always start at the minimum dose with monotherapy and then titrate up the medication

This approach helps minimize side effects and assess patient tolerance.

160
Q

What is the minimum length of treatment for schizophrenia?

A

6 months

This is necessary to allow for stabilization and symptom management.

161
Q

For a single episode of schizophrenia, how long should medication be continued?

A

6-24 months

Duration depends on the patient’s response and risk of relapse.

162
Q

What is the recommended treatment duration for the second episode of schizophrenia?

A

5 years medications

Extended treatment helps prevent relapse.

163
Q

What is the treatment approach for the third episode of schizophrenia?

A

Life-long medication

Ongoing treatment is necessary to manage chronic symptoms.

164
Q

What is Delusional Disorder?

A

A rare mental illness in which a patient experiences delusion without accompanying hallucinations, thought disorder, mood disorder, or flattening of affect.

Delusional Disorder is characterized by the presence of one or more delusions that persist for at least one month.

165
Q

What must a patient show for a diagnosis of Delusional Disorder?

A

Delusions in absence of any other psychotic symptoms or reversible cause (e.g., drugs).

This means that the delusions cannot be attributed to other mental health conditions or substance use.

166
Q

What is the main line of treatment for Delusional Disorder?

A

Psychotherapy (Cognitive Therapy) and Antipsychotics.

Cognitive Behavioral Therapy (CBT) is specifically mentioned as helping to challenge delusions and develop coping strategies.

167
Q

True or False: Delusional Disorder includes hallucinations.

A

False.

Patients with Delusional Disorder do not experience hallucinations.

168
Q

What role does social support play in the management of Delusional Disorder?

A

Social support is needed for appropriate housing and financial advice.

This support helps patients manage their everyday life and can aid in their overall treatment.

169
Q

Fill in the blank: CBT is offered to all patients to help challenge _______ and develop coping strategies.

A

delusions.

CBT is a common therapeutic approach used in various mental health disorders.

170
Q

What is an adjustment disorder?

A

A psychological response to identifiable stressors leading to significant distress or impairment.

171
Q

True or False: Adjustment disorders can only occur after a major life event.

A

False

Adjustment disorders can occur in response to various stressors, not just major life events.

172
Q

List some common stressors that may lead to an adjustment disorder.

A
  • Job loss
  • Divorce
  • Illness
  • Death of a loved one
  • Moving to a new location
173
Q

Fill in the blank: Adjustment disorders typically develop within _______ of the stressor.

A

[three months]

174
Q

What are some symptoms of adjustment disorder?

A
  • Anxiety
  • Depressed mood
  • Behavioral changes
  • Trouble concentrating
  • Difficulty sleeping
175
Q

How long do symptoms of adjustment disorder typically last?

A

Symptoms usually last for no longer than six months after the stressor has ended.

176
Q

True or False: Adjustment disorders are classified as a mental illness.

A

True

Adjustment disorders are recognized in the DSM-5 as a group of conditions related to stress.

177
Q

What is the primary treatment for adjustment disorders?

A

Psychotherapy is the primary treatment, often complemented by medication if necessary.

178
Q

Fill in the blank: The main goal of therapy for adjustment disorder is to help the individual _______.

A

[adapt to the stressor]

179
Q

What can happen if an adjustment disorder is left untreated?

A

It can lead to more severe mental health issues, such as anxiety disorders or major depressive disorder.

180
Q

List some therapeutic approaches used to treat adjustment disorders.

A
  • Cognitive Behavioral Therapy (CBT)
  • Supportive therapy
  • Family therapy
  • Group therapy
181
Q

What are psychotic defenses?

A

Pathological defenses that distort experiences to eliminate the need to deal with reality.

Examples include denial, distortion, and splitting.

182
Q

Name three types of psychotic defenses.

A
  • Denial
  • Distortion
  • Splitting

These defenses refuse to accept reality, reshape reality to meet internal needs, and involve intolerance of ambiguity.

183
Q

What is denial in the context of psychotic defenses?

A

Refusal to accept reality.

Denial involves rejecting the existence of a painful reality.

184
Q

What does distortion refer to in psychotic defenses?

A

A gross reshaping of reality to meet internal needs.

Distortion can involve altering perceptions to avoid facing uncomfortable truths.

185
Q

What is splitting in psychotic defenses?

A

Intolerance of ambiguity leading to self/others being perceived as wholly good or bad.

Splitting is often seen in borderline personality disorder.

186
Q

What are immature defenses?

A

Defense mechanisms that include projection, acting out, and projective identification.

These defenses are less effective and more self-destructive than neurotic defenses.

187
Q

Define projection in the context of immature defenses.

A

Attributing uncomfortable thoughts or feelings to others.

This mechanism allows individuals to avoid confronting their own negative emotions.

188
Q

What does acting out mean in terms of immature defenses?

A

Acting on thoughts or emotions forbidden by the superego.

Acting out often manifests as impulsive or reckless behavior.

189
Q

Explain projective identification.

A

The object of projection invokes in that person precisely the thoughts, feelings, or behaviors projected.

This can create a cycle where the projected feelings influence the behavior of others.

190
Q

What are neurotic defenses?

A

Defense mechanisms that tend to have short-term advantages but lead to problems when used in the longer term.

Neurotic defenses are more adaptive than immature defenses but can still create issues over time.