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1 Pharmacology > Medications affecting Reproduction > Flashcards

Medications affecting Reproduction Flashcards

1
Q

CEE

A

conjugated equine estrogen

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2
Q

*estrogen replacement

drug names

A
  • CEE
  • Estradiol
  • Ethyl Estradiol
  • Drospirenone
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3
Q

CEE, estradiol, ethyl estradiol, + drospirenone MOA/route

A
  • HRT (horm therapy)
  • prevent ovulation

-often PO or patch

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4
Q

CEE, estradiol, ethyl estradiol, + drospirenone Tx

A
  • contraception along w progestin
  • acne
  • relief of severe postmeno s/s
  • prevention of postmeno OSTEOPOROSIS
  • prostate cancer
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5
Q

CEE, estradiol, ethyl estradiol, + drospirenone

CI

A
  • *cigarette/nicotine + <35yr+
  • Cat X
  • fam Hx of hrt disease
  • atypical vaginal bleeding
  • breast or estrogen-dependent CA
  • Hx of thromboembolic disease
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6
Q

*CEE, estradiol, ethyl estradiol, + drospirenone

AE

A
  • endometrial, breast, ovarian cancer

- hypercoagulability

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7
Q

____, is administered along with estrogen to decrease the risk of endometrial, breast, + ovarian cancer

A

progestins

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8
Q

CEE, estradiol, ethyl estradiol, + drospirenone causes hypercoagulability which can lead to…

A
  • DVT
  • stroke
  • MI
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9
Q

**CEE, estradiol, ethyl estradiol, + drospirenone

RN/teach

A
  • endometrial biopsy Q2yrs
  • breast exam Qyr
  • avoid cig/nicotine esp 35+
  • monitor for DVT
  • DO NOT place patch near breast + waistline
  • admin same time each day
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10
Q

progesterones vs progestins

A

progestines are synthetic

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11
Q

*progesterone replacement

drug names

A

medroxyprogesterone + norethindrone

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12
Q

medroxyprogesterone + norethindrone

Tx

A
  • contraception
  • lowers A/E of estrogen in hormonal therapy
  • protects fr endometrial cancer
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13
Q

medroxyprogesterone + norethindrone

A/E

A

-breast cancer
-thromboembolic events
-breakthrough bleeding
-amenorrhea
migraines

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14
Q

medroxyprogesterone + norethindrone

CI

A
  • cat X

- Hx of DVT or CVD

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15
Q

*medroxyprogesterone + norethindrone

RN/teach

A
  • *anticipate withdrawal bleeding 3-7 days after stopping the medication
  • —–if the A/E is amenorrhea, it makes sense that bleeding would recommence
  • smoking incr risk for thrombophlebitis
  • IM injections 4x/yr
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16
Q

why would we administer ethinyl estradiol + norethindrone as a combination?

A

combo med has fewer side effects

-reduces blood loss + muscle cramping

17
Q

combo med: ethinyl estradiol + norethindrone

MOA/routes

A
  • blocks FSH/LH

- via transdermal patch, contraceptive ring, parenteral depot, etonogestral implants

18
Q

combo med: ethinyl estradiol + norethindrone

Tx

A
  • contraception

- protects against endometrial + ovarian cancer

19
Q

combo med: ethinyl estradiol + norethindrone

A/E

A
  • hyperglycemia
  • hyper-K
  • thromboembolic events
  • breakthru bleeding
  • breast cancer
20
Q

nursing safety w all hormone therapy?

A

careful w handling

21
Q

depot injections

A

-injection formulation of a med which RELEASES SLOWLY OVER TIME

  • IM or subQ
  • —not IV! that is literally the opposite of slowly over time
22
Q

what is the longest-acting contraception?

A

IUD-10 yrs

23
Q

androgen replacement

drug names

A

testosterone HRT + oxandrolone

24
Q

*testosterone HRT + oxandrolone

Tx

A
  • cachexia

- longevity + quality of life

25
Q

testosterone HRT + oxandrolone

A/E

A
  • virilization effects
  • epiphyseal closure (in kids)
  • hepatitis
  • hyper-cholesterol
  • polycythemia
  • hyper-Ca
  • hypoglycemia
26
Q

testosterone HRT + oxandrolone

CI

A
  • cat X

- prostate/breast cancer

27
Q

testosterone HRT + oxandrolone

RN teaching

A

w gel formula, wash hands after every application to reduce risk of SKIN TO SKIN TRANSFER
-cover application w clothing after gel has dried + wash off before skin to skin contact

28
Q

BPH drugs

A

5-alpha: finasteride + dutasteride

alpha 1: tamsulosin + doxazosin

29
Q

finasteride + dutasteride

MOA

A

blocks conversion of TESTOSTERONE

30
Q

finasteride + dutasteride

A/E

A
  • decr libido
  • gynecomastia
  • decr PSA levels
31
Q

finasteride + dutasteride

onset

A

lifelong therapy

long lonely ride

32
Q

finasteride + dutasteride

RN teaching

A

female clients shouldnt handle medication
–wear gloves
–avoid semen
onset takes 6 mos or more

33
Q

tamsulosin + doxazosin

Tx

A
  • BPH
  • HTN
  • helps w urination (relax bladder neck + prostate muscle)
34
Q

tamsulosin + doxazosin

A/E

A
  • hypotension
  • dizzy
  • retro ejac
  • floppy iris syndrome
35
Q

tamsulosin + doxazosin

CI

A

clints using sildenafil or NTG

  • Hx of syncope
  • cataract surgery
36
Q

tamsulosin + doxazosin

RN/teaching

A

lifelong

  • 30 min after meals
  • onset 48hr

1 Pharmacology (33 decks)

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